Stroke induces inflammatory activation of the aortic endothelium

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Fig. 3 Stroke induces inflammatory activation of the aortic endothelium. Stroke induces inflammatory activation of the aortic endothelium. (A) Relative expression (RE) of Icam1 and Vcam1 transcription in whole-aorta lysates 3 days after sham or stroke (U test, n = 5 per group). (B) Vascular cell adhesion molecule–1 (VCAM-1)–targeted iron particles were used for molecular magnetic resonance imaging (MRI) of endothelial activation in vivo before and after stroke. Representative longitudinal and sagittal MRI images of aortic root area 5 days (5d) after stroke. (C) Representative comparison of the VCAM-1 signal volume of the same aortic valve before and 5 days after stroke surgery. (D) Quantification of VCAM-1 signal volume 5 days after stroke compared to baseline (U test, n = 5 per group). (E) Schematic illustration of experiments shown in (F). Wild-type (WT) mice received either stroke or sham surgery; 4 hours later, plasma was collected and used for conditioning media in murine aortic endothelial cell (MAEC) cultures. (F) RE of Icam1, Vcam1, and Il6 mRNA in MAECs after being incubated with stroke or sham plasma and treated with soluble form of receptor for advanced glycation end products (sRAGE) (10 ng/ml) or vehicle (H test, n = 6 to 8 per group). For control conditions, fetal calf serum (FCS)–supplemented media without cytokine stimulus or with recombinant tumor necrosis factor–α (TNF-α; 20 ng/ml) were used. *P < 0.05, **P < 0.01, ***P < 0.001. Stefan Roth et al., Sci Transl Med 2018;10:eaao1313 Published by AAAS