Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma Eve Denton, MBBS (Hons), MPH, FRACP, Fiona Hore-Lacy, BNutSci (Hons),

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Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma Eve Denton, MBBS (Hons), MPH, FRACP, Fiona Hore-Lacy, BNutSci (Hons), Naghmeh Radhakrishna, MBBS, FRACP, Annie Gilbert, BBus (OAdmin), MIS, TunnRen Tay, MBBS, MRCP, Joy Lee, BHB, MBChB, FRACP, Eli Dabscheck, MBBS, FRACP, Erin S. Harvey, PhD, Lakmini Bulathsinhala, MPH, James Fingleton, PhD, David Price, FRCGP, Peter G. Gibson, MBBS, FRACP, Robyn O'Hehir, FAHMS, PhD, FRACP, Mark Hew, MBBS, PhD, FRACP The Journal of Allergy and Clinical Immunology: In Practice Volume 7, Issue 5, Pages 1440-1449 (May 2019) DOI: 10.1016/j.jaip.2019.02.042 Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 1 Key features of the Severe Asthma Global Evaluation platform. The Journal of Allergy and Clinical Immunology: In Practice 2019 7, 1440-1449DOI: (10.1016/j.jaip.2019.02.042) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 2 Protocolized assessment for difficult-to-treat and severe asthma incorporating the electronic system with automatically generated outputs in red. SAGE, Severe Asthma Global Evaluation The Journal of Allergy and Clinical Immunology: In Practice 2019 7, 1440-1449DOI: (10.1016/j.jaip.2019.02.042) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 3 Asthma module component of the Severe Asthma Global Assessment showing details of the Asthma Diagnosis section. FEV1, Forced expiratory volume in 1 second; PEF, peak expiratory flow. The Journal of Allergy and Clinical Immunology: In Practice 2019 7, 1440-1449DOI: (10.1016/j.jaip.2019.02.042) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 4 Comorbidity module component of the Severe Asthma Global Assessment showing details of the Vocal Cord Dysfunction (VCD) section. COPD, Chronic obstructive pulmonary disease. The Journal of Allergy and Clinical Immunology: In Practice 2019 7, 1440-1449DOI: (10.1016/j.jaip.2019.02.042) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 5 Severe Asthma Global Evaluation Report that is automatically generated from information entered by the clinician in the Asthma, Comorbidity, and Management Plan modules. AHR, Airway hyper-responsiveness; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; ICS, inhaled corticosteroids; LABA, long-acting β-agonists; PEF, peak expiratory flow; VAO, variable airflow obstruction. The Journal of Allergy and Clinical Immunology: In Practice 2019 7, 1440-1449DOI: (10.1016/j.jaip.2019.02.042) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions