ASCO/NCODA Oral Chemotherapy Dispensing Standards Initiative Michael Reff, RPh, MBA Executive Director / Founder of NCODA Erin Kennedy, MHSc Clinical Practice Guidelines Specialist Amy Evers, BSN, RN, OCN Associate Director, ASCO’s QOPI Certification Program 45 min

Championing our Future Passion for Patients Imagine…Tipping Point Create Positive Change for Patients Develop Quality Standards Collaborate with Payers Accomplish Beyond the First Fill Capabilities Strengthen Mission Success Championing our Future

About ASCO World’s leading professional organization representing physicians caring for those with cancer Founded in 1964 Headquarters in Alexandria, VA Serves nearly 45,000 members ASCO Mission: Conquering cancer though research, education, and promotion of the highest quality patient care. Improves cancer care through: Scientific meetings Educational programs Peer-reviewed journals

ASCO Promotes and Provides for: Lifelong Learning for Oncology Professionals Cancer Research Improved Environment for Oncology Practice Access to Quality Cancer Care Expertise of Global Network of Oncologists Educated and Informed Cancer Patients

ASCO Membership Global network of nearly 45,000 oncology professionals Only organization representing all oncology subspecialties Members benefit from worldwide, cross-discipline network of professional and personal expertise 30% of members are international Members represent more than 120 countries

ASCO Network American Society of Clinical Oncology www.asco.org Journal of Clinical Oncology  jco.ascopubs.org  Journal of Oncology Practice  jop.ascopubs.org   ASCO Connection  connection.asco.org   ASCO University  university.asco.org  CancerLinQ asco.org/cancerlinq Cancer Portals  asco.org/cancerportals Conquer Cancer Foundation CONQUER.org  Cancer.Net  cancer.net  Quality Oncology Practice Initiative  qopi.asco.org  QCP – QOPI Certification Program qopi.asco.org

ASCO Guidelines and Standards ASCO Guidelines address a wide range of cancer treatment, diagnosis, and management issues. Also publish guideline endorsements, adaptations, standards and provisional clinical opinions (PCOs) Annually, our team has 25 new guidelines, 15 updates in progress There are > 1500 guideline or standards volunteers ASCO has collaborated with 27 organizations on guideline development ASCO guidelines consistently are among the most accessed Journal of Clinical Oncology articles  First guideline published in 1994. Briefly note the difference between a guideline and standard.

ASCO Guidelines and standards Standards/Guideline Examples And here’s an example of a standard that we recently released Tie back to what Mike said about the increased need for standards for in the world of oral chemotherapy

The Development Process Invite Co-Chairs and panelists to serve on the panel Develop Protocol Systematic Review conducted A critical assessment and evaluation of all research studies that address a particular clinical or process issue; an organized method of locating, assembling, and evaluating a body of literature on a particular topic using a set of specific criteria. Consensus Methodology Have multidisciplinary panel; Protocol helps with scope creep. Defines questions going to be asked, inclusion/exclusion criteria, populations, intervention, etc. Systematic review can be large or small depending on the topic. Try to get the highest quality evidence-meta-anayses, RCTs, etc. Sometimes need case studies. The more narrow the search the better. First do title search, abstract search, full text. Extract data into tables Rate the evidence and recommendations: three core domains of 1) quality appraisal, 2) rating the strength of the evidence, and 3) rating the strength of standards.

Timeline and deliverables Current status: Systematic review in progress February - March 2019: finalize systematic review March – April 2019: finalize standards statements with Expert Panel Goal: project completion Q2 2019 Key publication in Journal of Clinical Oncology

Dissemination ASCO Guidelines App Journal of Clinical Oncology Clinical Tools and Resources Slide Sets Recommendations Tables Flow Sheets/Algorithms Decision aids/discussion guides Patient Guides Podcasts (NEW) Pocket Cards ASCO University podcasts/courses Email List Serves State Societies, OPI, targeted Committees Planning Web and Print Publication (ex. NCODA’s Oncolytics Today)

ASCO/NCODA Oral Chemotherapy Dispensing Standards Early discussions of shared values and standards ASCO and NCODA Concept to address gap of oral chemotherapy dispensing Future potential of planning to work with NCODA to help speak with payers and employer groups to go Beyond the First Fill for a better patient care standard

Working Together, We become Stronger