Component-resolved in vitro diagnosis of hazelnut allergy in Europe

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Presentation transcript:

Component-resolved in vitro diagnosis of hazelnut allergy in Europe Kirsten Skamstrup Hansen, MD, PhD, Barbara K. Ballmer-Weber, MD, PhD, Joaquin Sastre, MD, PhD, Jonas Lidholm, PhD, Kerstin Andersson, PhD, Hubert Oberhofer, MD, Magdalena Lluch-Bernal, MD, Jonas Östling, PhD, Lars Mattsson, PhD, Frauke Schocker, PhD, Stefan Vieths, PhD, Lars K. Poulsen, PhD Journal of Allergy and Clinical Immunology Volume 123, Issue 5, Pages 1134-1141.e3 (May 2009) DOI: 10.1016/j.jaci.2009.02.005 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Level of IgE for all hazelnut allergens. The y axis represents the common log scale. Hatched lines indicate cutoff values at 0.1 and 0.35 kUA/L. The number of values of less than 0.1 kUA/L is indicated for each plot. The median value for each data set is marked by a short horizontal line. Lines at the top show significant differences (P ≤ .05). HN, Patients with hazelnut allergy; Po, control subjects with pollen allergy; DK, Denmark; CH, Switzerland; E, Spain. Journal of Allergy and Clinical Immunology 2009 123, 1134-1141.e3DOI: (10.1016/j.jaci.2009.02.005) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Receiver operating characteristic curves of sensitivity and specificity of IgE analyses at different cutoff levels: 0.1, 0.35, 0.7, 3.5, and 17.5 kUA/L. Sensitivity is shown along the y-axis, and 1-specificity is shown along the x-axis. Dashed lines represent the nonatopic control group, and dotted lines represent the control subjects with pollen allergy. The solid line indicates x = y. CH, Switzerland; DK, Denmark; E, Spain. Journal of Allergy and Clinical Immunology 2009 123, 1134-1141.e3DOI: (10.1016/j.jaci.2009.02.005) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions