J. van Tiel, M. Siebelt, J. H. Waarsing, T. M. Piscaer, M

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Presentation transcript:

CT arthrography of the human knee to measure cartilage quality with low radiation dose J. van Tiel, M. Siebelt, J.H. Waarsing, T.M. Piscaer, M. van Straten, R. Booij, M.L. Dijkshoorn, G.J. Kleinrensink, J.A.N. Verhaar, G.P. Krestin, H. Weinans, E.H.G. Oei Osteoarthritis and Cartilage Volume 20, Issue 7, Pages 678-685 (July 2012) DOI: 10.1016/j.joca.2012.03.007 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 3D representation of the seven analyzed large cartilage ROIs per knee joint: (A) pMC/pLC; (B) wbMC/wbLC; (C) wbMP/wbLP and mpP. Osteoarthritis and Cartilage 2012 20, 678-685DOI: (10.1016/j.joca.2012.03.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 EPIC-μCT datasets are used as reference for the spatial sGAG distribution of cartilage (A). Using a fixed X-ray attenuation threshold of 150HU in all CTa datasets (B, only maximum radiation dose shown), a mask for high and low sGAG content was created (C, D). The masks were used as an overlay of EPIC-μCT cartilage (E, F). Within the masked EPIC-μCT images, the number of pixels correctly and incorrectly predicted as having a high and low sGAG content by CTa was calculated (G, H). #: high sGAG content. *: low sGAG content. Osteoarthritis and Cartilage 2012 20, 678-685DOI: (10.1016/j.joca.2012.03.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Correlation plots of mean attenuation from EPIC-μCT and CTa acquired using six different radiation doses. A: maximum radiation dose (n = 33); B: 50% of the maximum radiation dose (n = 33); C: 40% of the maximum radiation dose (n = 33); D: 30% of the maximum radiation dose (n = 33); E: 20% of the maximum radiation dose (n = 33); F: 10% of the maximum radiation dose (n = 33). The dashed lines indicate the 95% confidence interval of the best fit regression line. Osteoarthritis and Cartilage 2012 20, 678-685DOI: (10.1016/j.joca.2012.03.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Bar graphs showing the percentage of pixels incorrectly predicted as high and low sGAG content by the different radiation doses (maximum, 50%, 40%, 30%, 20% and 10% of the maximum dose) used in this study. Whiskers show the 95% confidence interval of the mean. Osteoarthritis and Cartilage 2012 20, 678-685DOI: (10.1016/j.joca.2012.03.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Registered images of both EPIC-μCT and CTa acquired using different radiation doses (maximum radiation dose, 50%, 40%, 30%, 20% and 10% of the maximum radiation dose) per scan. The attenuation of cartilage regions is visualized in colour and representative for the sGAG content of the cartilage. High attenuation values represent low sGAG content and low attenuation values represent high sGAG content. Osteoarthritis and Cartilage 2012 20, 678-685DOI: (10.1016/j.joca.2012.03.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions