Chikara Kokubu, Junji Takeda Cell Stem Cell

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Presentation transcript:

When Half Is Better Than the Whole: Advances in Haploid Embryonic Stem Cell Technology Chikara Kokubu, Junji Takeda Cell Stem Cell Volume 14, Issue 3, Pages 265-267 (March 2014) DOI: 10.1016/j.stem.2014.02.001 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Haploid Embryonic Stem Cell System as a Versatile Genetic Tool in Rodents (A) Intracytoplasmic rat androgenetic haploid ESC injection (ICAI) contributes to production of both transgenic (RFP+) and knockout (Scn4b+/−) mutant rats. (B) Gene-trap mutagenesis of mouse parthenogenetic haploid ESCs allows loss-of-function genetic screening to identify genes (Zfp706 and Pum1) that promote exit from the self-renewal state. Blue and red rectangles represent the paternal and maternal sets of haploid chromosomes, respectively. Yellow stars represent mutations. SpB indicates the second polar body. Cell Stem Cell 2014 14, 265-267DOI: (10.1016/j.stem.2014.02.001) Copyright © 2014 Elsevier Inc. Terms and Conditions