Kaplan-Meier plots of hHF: DPP-4i and SU cohort with baseline CVD (panel A); saxagliptin and sitagliptin cohorts with baseline CVD (panel B); DPP-4i and SU cohort with no baseline CVD (panel C); saxagliptin and sitagliptin cohorts with no baseline CVD (panel D). *HR treating SUs as reference (HR < 1 indicates a lower rate for DPP-4i) 0.946 (95% CI 0.778–1.151), P = 0.580. †HR treating sitagliptin as reference (HR < 1 indicates a lower rate for saxagliptin) 0.945 (95% CI 0.699–1.278), P = 0.712. ‡HR treating SUs as reference (HR < 1 indicates a lower rate for DPP-4i) 0.585 (95% CI 0.384–0.892), P = 0.013. §HR treating sitagliptin as reference (HR < 1 indicates a lower rate for saxagliptin) 0.990 (95% CI 0.560–1.749), P = 0.972. Kaplan-Meier plots of hHF: DPP-4i and SU cohort with baseline CVD (panel A); saxagliptin and sitagliptin cohorts with baseline CVD (panel B); DPP-4i and SU cohort with no baseline CVD (panel C); saxagliptin and sitagliptin cohorts with no baseline CVD (panel D). *HR treating SUs as reference (HR < 1 indicates a lower rate for DPP-4i) 0.946 (95% CI 0.778–1.151), P = 0.580. †HR treating sitagliptin as reference (HR < 1 indicates a lower rate for saxagliptin) 0.945 (95% CI 0.699–1.278), P = 0.712. ‡HR treating SUs as reference (HR < 1 indicates a lower rate for DPP-4i) 0.585 (95% CI 0.384–0.892), P = 0.013. §HR treating sitagliptin as reference (HR < 1 indicates a lower rate for saxagliptin) 0.990 (95% CI 0.560–1.749), P = 0.972. Dotted lines around the survival curve point estimates represent 95% confidence bands. Alex Z. Fu et al. Dia Care 2016;39:726-734 ©2016 by American Diabetes Association