Association with Genetic Variants in the IL-23 and NF-κB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease  Pernilla Nikamo, Josefin Lysell, Mona Ståhle  Journal of Investigative Dermatology  Volume 135, Issue 8, Pages 1969-1976 (August 2015) DOI: 10.1038/jid.2015.103 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Association of markers analyzed in psoriasis subjects. Stratification of psoriasis patients reveals association in the severe phenotype. Odds ratios for case–control study are shown, and a case–case study exposes distinct genetic profiles in severe versus mild psoriasis. Three of the most significantly associated genes remained significant after correction: IL23R, IL23A, and NFKBIL1 (P<0.05). *P<0.05, **P<0.01, and ***P<0.001. Journal of Investigative Dermatology 2015 135, 1969-1976DOI: (10.1038/jid.2015.103) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Additive interaction in severe psoriasis. Calculating biological interaction in severe subjects using R program results showing additive interaction between (a) rs610604 (TNFAIP3) and rs2255798 (NFKBIL1), APp 0.001, AP 0.554, 95% CI 0.225–0.883; (b) rs3762999 (TNIP1) and rs2255798 (NFKBIL1), APp 0.000001, AP 0.503, 95% CI 0.301–0.705; (c) rs2201841 (IL23R) and HLA-C, APp 0.002, AP 0.364, 95% CI 0.133–0.595, as well as (d) rs2293970 (NFKB1) and HLA-C, APp 0.0002, AP 0.541, 95% CI 0.252–0.830. Interactions in (b) and (d) remain significant after correction for multiple testing (P<0.05). Journal of Investigative Dermatology 2015 135, 1969-1976DOI: (10.1038/jid.2015.103) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions