Wayel Jassem, Nigel D. Heaton Kidney International

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The role of mitochondria in ischemia/reperfusion injury in organ transplantation Wayel Jassem, Nigel D. Heaton Kidney International Volume 66, Issue 2, Pages 514-517 (August 2004) DOI: 10.1111/j.1523-1755.2004.761_9.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Schematic illustration of mitochondrial oxidative phosphorylation under physiologic conditions (A) and the major changes during ischemia (B) and reperfusion (C). The oxidative phosphorylation takes place within the mitochondrial inner membrane through complexes of the electron transport chain (complexes I to IV), complex V [adenosine triphosphate (ATP) synthase], and the adenine nucleotide translocator (ANT). Under normal conditions, most of the O2 is reduced at the level of complex IV [cytochrome c oxidase (COX)]. Small amount of O2 is reduced to superoxide by single electrons that leak from the electron transport chain. For more details see the test. Abbreviations are: CoQ, coenzyme Q; Cyt c, cytochrome C; ADP, adenosine diphosphate; Pi, inorganic phosphate; MnSOD, manganese superoxide dismutase; GSH, glutathione-stimulating hormone Kidney International 2004 66, 514-517DOI: (10.1111/j.1523-1755.2004.761_9.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Reactive oxygen species (ROS) production and mitochondrial antioxidant system. For details see test. Abbreviations are: MnSOD, manganese superoxide dismutase; NADP, nicotinamide adenine dinucleotide phosphate; NADPH, reduced nicotinamide adenine dinucleotide phosphate; GSH, glutathione-stimulating hormone; GSSG, oxidized glutathione. Kidney International 2004 66, 514-517DOI: (10.1111/j.1523-1755.2004.761_9.x) Copyright © 2004 International Society of Nephrology Terms and Conditions