Effect of collagen-induced arthritis (CIA) and 3,4-dichloropropionaniline (DCPA) on osteoclast bone interface density determined by ATPa3 (TCIRG) labelling,

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Presentation transcript:

Effect of collagen-induced arthritis (CIA) and 3,4-dichloropropionaniline (DCPA) on osteoclast bone interface density determined by ATPa3 (TCIRG) labelling, and effect on CD3 T cells. Effect of collagen-induced arthritis (CIA) and 3,4-dichloropropionaniline (DCPA) on osteoclast bone interface density determined by ATPa3 (TCIRG) labelling, and effect on CD3 T cells. (A–C) Typical section of each specimen type with ATPa3 antibody labelling. (D) Blindly scored area of ATPa3 labelling on bone. Mean fraction±SEM; n=5 for untreated and 9 each for CIA animals treated with 0 (blue bar) or 21 (yellow bar) mg/kg/day DCPA (right bar). All groups are statistically different with high confidence. (E) CIA animals have more T cells per section area, but T cell density in infiltrates is not reduced by DCPA treatment. The DCPA treatment greatly reduces inflammatory volume (figures 1 and 3) so total T cells will be far fewer. (F–H) Typical sections with CD3 antibody labelling. Note T cells in the ligaments of a no-CIA animal (arrow, F). Harry C Blair et al. RMD Open 2016;2:e000093 Copyright © BMJ Publishing Group & EULAR. All rights reserved.