Volume 58, Issue 4, Pages (October 2000)

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Volume 58, Issue 4, Pages 1440-1449 (October 2000) Down-regulation of human osteoblast PTH/PTHrP receptor mRNA in end-stage renal failure Michael L. Picton, Philip R. Moore, E. Barbara Mawer, David Houghton, Anthony J. Freemont, Alastair J. Hutchison, Ram Gokal, Judith A. Hoyland Kidney International Volume 58, Issue 4, Pages 1440-1449 (October 2000) DOI: 10.1046/j.1523-1755.2000.00306.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Photomicrograph showing PTH1R mRNA expression [visualized as black (silver) autoradiographic grains] by osteoblasts (arrow) lining the bone surface in (a and b) renal hyperparathyroid bone (a, magnification ×50; b, magnification ×200), (c and d) normal bone (magnification ×250), and (e and f) normal healing fracture callus (e, magnification ×50; f, magnification ×200). Note the increase in signal seen in nonuremic osteoblasts compared with those in renal bone. Kidney International 2000 58, 1440-1449DOI: (10.1046/j.1523-1755.2000.00306.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Photomicrograph showing PTH1R mRNA expression [visualized as black (silver) autoradiographic grains] by osteoblasts (arrow) lining the bone surface in (a and b) renal hyperparathyroid bone (a, magnification ×50; b, magnification ×200), (c and d) normal bone (magnification ×250), and (e and f) normal healing fracture callus (e, magnification ×50; f, magnification ×200). Note the increase in signal seen in nonuremic osteoblasts compared with those in renal bone. Kidney International 2000 58, 1440-1449DOI: (10.1046/j.1523-1755.2000.00306.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Photomicrograph showing PTH1R mRNA expression by osteoclasts in renal hyperparathyroid bone (a, magnification ×100) and Pagetic bone (b, magnification ×100). Note the increase in hybridization signal in Pagetic osteoclasts. Kidney International 2000 58, 1440-1449DOI: (10.1046/j.1523-1755.2000.00306.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Levels of osteoblast PTH1R mRNA signal in different bone states. PTH1R mRNA hybridization signal in osteoblasts from fracture callus (F1-2), Pagetic bone (P1-2), normal bone (N1-4), renal hyperparathyroid (H1-9), and diabetic-adynamic bone (A1-4). Mean signal density values (per unit area of cell) with 95% CI are presented for each individual. Kidney International 2000 58, 1440-1449DOI: (10.1046/j.1523-1755.2000.00306.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 PTH serum levels, serum phosphate, ionized calcium, serum 1,25(OH)2D3 and age of subject at time of biopsy correlated with PTH1R mRNA hybridization signal density (N = 13 renal bone biopsies). Kidney International 2000 58, 1440-1449DOI: (10.1046/j.1523-1755.2000.00306.x) Copyright © 2000 International Society of Nephrology Terms and Conditions