David M. Brass, PhD, John W. Hollingsworth, MD, Michael B

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Presentation transcript:

The IL-1 type 1 receptor is required for the development of LPS-induced airways disease David M. Brass, PhD, John W. Hollingsworth, MD, Michael B. Fessler, MD, Jordan D. Savov, MD, PhD, Abby B. Maxwell, BS, Gregory S. Whitehead, MS, Lauranell H. Burch, PhD, David A. Schwartz, MD, MPH Journal of Allergy and Clinical Immunology Volume 120, Issue 1, Pages 121-127 (July 2007) DOI: 10.1016/j.jaci.2007.03.051 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Time course of lung lavage fluid mean concentration of total cells (A), percent neutrophils (B), and percentage of macrophages (C). Error bars are the SE. ∗P < .05. Journal of Allergy and Clinical Immunology 2007 120, 121-127DOI: (10.1016/j.jaci.2007.03.051) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Time course of lung lavage fluid mean concentration of TNF-α (A), IL-1β (B), and IL-6 (C). Error bars are the SE. ∗P < .05. Journal of Allergy and Clinical Immunology 2007 120, 121-127DOI: (10.1016/j.jaci.2007.03.051) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Superoxide production by lavaged neutrophils, at baseline or stimulated with PMA or fMLP, from C57BL/6 and C57BL/6IL-1R1–/– mice after a single LPS inhalation challenge. Error bars are the SE. ∗P < .05. Journal of Allergy and Clinical Immunology 2007 120, 121-127DOI: (10.1016/j.jaci.2007.03.051) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Stereologic measures of the submucosal area from small, medium, and large airways from C57BL/6 and C57BL/6IL-1R1–/– mice exposed to LPS for 1 month and allowed to recover for 3 days. Data from age-matched air-exposed C57BL/6 and C57BL/6IL-1R1–/– are also presented. Error bars are the SE. ∗P < .05. Journal of Allergy and Clinical Immunology 2007 120, 121-127DOI: (10.1016/j.jaci.2007.03.051) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 BrdU labeling in small, medium, and large airway submucosa in C57BL/6 and C57BL/6IL-1R1–/– mice at baseline, after 1 week, and in mice exposed to LPS for 4 weeks and allowed to recover for 3 days. Error bars are the SE. #P < .05 compared with baseline; ∗P < .05 C57BL/6 compared with C57BL/6IL-1R1–/–. Journal of Allergy and Clinical Immunology 2007 120, 121-127DOI: (10.1016/j.jaci.2007.03.051) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 6 Real-time quantitative PCR for expression of type III α-3 procollagen and TIMP1 mRNA expression in C57BL/6 and C57BL/6IL-1R1–/– mouse lung after 1 week and 4 weeks. Dotted lines represent no change. Error bars are the SE. ∗P < .05 C57BL/6 compared with C57BL/6IL-1R1–/–. Journal of Allergy and Clinical Immunology 2007 120, 121-127DOI: (10.1016/j.jaci.2007.03.051) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions