Helena M. Viola et al. BTS 2018;3:

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Helena M. Viola et al. BTS 2018;3:391-402 Long-Term, High-Dose Treatment of 24-Week-Old mdx Mice With PMO Prevents Development of mdx Cardiomyopathy and Is Not Toxic (A) Representative images of serial echocardiographic measurements from PMO-treated mdx mice and untreated wt and mdx mice pre- (24 weeks) and post-treatment (Rx; 43 weeks). (B) Mean ± SEM of all echocardiographic measurements. *p < 0.05 compared with untreated age-matched wt; #p < 0.05 compared with untreated age-matched mdx. (C) Mean ± SEM of urea, creatinine, and alanine transaminase (ALT) concentrations in PMO-treated mice compared to untreated mdx mice. bpm = beats/min; FS = fractional shortening; HR = heart rate; IVDS = intraventricular septum in diastole; IVSS = intraventricular septum in systole; LVEDD = left ventricular end-diastolic diameter; LVESD = left ventricular end-systolic diameter; LVDPW = left ventricular posterior wall in diastole; LVSPW = left ventricular posterior wall in systole; PMO Rx = 40 mg/kg PMO 3× per week for 19 weeks; other abbreviations as in Figure 1. Helena M. Viola et al. BTS 2018;3:391-402 2018 The Authors