Nonsteroidal Anti-Inflammatory Drugs and Hepatic Toxicity: A Systematic Review of Randomized Controlled Trials in Arthritis Patients Alaa Rostom, Lawrence.

Slides:

Advertisements

Similar presentations

Celiac Disease Genetics: Current Concepts and Practical Applications Ludvig M. Sollid, Benedicte A. Lie Clinical Gastroenterology and Hepatology Volume.

Advertisements

Effect of chronic intake of NSAIDs and cyclooxygenase 2—selective inhibitors on esophageal cancer incidence Marc Bardou, Alan N. Barkun, Joumana Ghosn,

Abnormal Liver Tests and Fatty Liver on Ultrasound

Thrombocytopenia With Abnormal Liver Function Tests

Volume 120, Issue 3, Pages (February 2001)

Incorrect Calculation and Inappropriate Interpretation: Accuracy of International Guidelines for Identifying Significant Fibrosis in e Antigen–Negative.

Noncardiac Chest Pain Clinical Gastroenterology and Hepatology

Millie D. Long, Bruce E. Sands

Co-prescription of Gastroprotective Agents and Their Efficacy in Elderly Patients Taking Nonsteroidal Anti-inflammatory Drugs: A Systematic Review of.

Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials Kenneth R. McQuaid, MD, Loren.

Gauree Gupta, Ebbing Lautenbach, James D. Lewis

Volume 387, Issue 10033, Pages (May 2016)

Psychological Stress Increases Risk for Peptic Ulcer, Regardless of Helicobacter pylori Infection or Use of Nonsteroidal Anti-inflammatory Drugs Susan.

Effect of the Prebiotic Oligofructose on Relapse of Clostridium difficile-Associated Diarrhea: A Randomized, Controlled Study Stephen Lewis, Stephen.

Patient-Reported Outcome Measures for Use in Clinical Trials and Clinical Practice in Inflammatory Bowel Diseases: A Systematic Review Marin J. de Jong,

Stephen A. Harrison, MD, FACP Clinical Gastroenterology and Hepatology

Evaluation and Treatment of Obesity

Short-Bowel Syndrome Clinical Gastroenterology and Hepatology

Diagnosing autoimmune hepatitis in children: Is the International Autoimmune Hepatitis Group scoring system useful? Regan L. Ebbeson, Richard A. Schreiber

Definition, Pathogenesis, and Management of That Cursed Dyspepsia

Yasuhiko Sugawara, Masatoshi Makuuchi

Genetics of Colonic Polyposis

Gastrointestinal Effects of NSAIDs and Coxibs

Volume 135, Issue 5, Pages (November 2008)

Jessica L. Mellinger, Michael L. Volk

4-Liter Split-Dose Polyethylene Glycol Is Superior to Other Bowel Preparations, Based on Systematic Review and Meta-analysis Brintha K. Enestvedt, Christina.

Incidence of Statin Hepatotoxicity in Patients With Hepatitis C

Michael Charlton Clinical Gastroenterology and Hepatology

Anouk Dev, Keyur Patel, Andrew Conrad, Lawrence M. Blatt, John G

Leon P. McLean, Jonathan S. Chun, Raymond K. Cross

Severe Constipation Clinical Gastroenterology and Hepatology

Mild Enteropathy Celiac Disease: A Wolf in Sheep's Clothing?

Ronnie Fass, Stephen J. Sontag, Barry Traxler, Mark Sostek

Medical management of osteoarthritis

Chan Wah Kheong, Nik Raihan Nik Mustapha, Sanjiv Mahadeva

Abnormal Liver Tests and Fatty Liver on Ultrasound

Importance of Specimen Size in Accurate Needle Liver Biopsy Evaluation of Patients With Chronic Hepatitis C Thomas D. Schiano, Samia Azeem, Carol A.

Effect of chronic intake of NSAIDs and cyclooxygenase 2—selective inhibitors on esophageal cancer incidence Marc Bardou, Alan N. Barkun, Joumana Ghosn,

David H. Bruining, William J. Sandborn

Histologic Changes in Liver Tissue From Patients With Chronic Hepatitis B and Minimal Increases in Levels of Alanine Aminotransferase: A Meta-analysis.

Development of Hepatocellular Carcinoma After Seroclearance of Hepatitis B Surface Antigen Myron John Tong, Michael Ong Nguyen, Lori Terese Tong, Lawrence.

Lise L. Kjaergard, Sarah L. Frederiksen, Christian Gluud

Patient-Reported Outcomes of Cirrhosis

Gastrointestinal Safety of Cyclooxygenase-2 Inhibitors: A Cochrane Collaboration Systematic Review Alaa Rostom, Katherine Muir, Catherine Dubé, Emilie.

Albert B. Knapp, Lynn Ladetsky

Esophageal variceal bleeding: Primary prophylaxis

Alan Bonder, MD, Nezam H. Afdhal, MD

18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children Man-fung Yuen, Wei-ling Lim,

Suna Yapali, MD, Anna S. Lok, MD, FRCP

The Utility of Intraluminal Impedance in Patients With Gastroesophageal Reflux Disease–Like Symptoms But Normal Endoscopy and 24-Hour pH Testing Michael.

Hannah I. Awai, Kimberly P. Newton, Claude B

No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents Liam Zakko, Tarun Rustagi, Maura Douglas, Loren.

Chronic Diarrhea Clinical Gastroenterology and Hepatology

Nicolas Williet, William J. Sandborn, Laurent Peyrin–Biroulet

Hepatic Cyst? Clinical Gastroenterology and Hepatology

Volume 147, Issue 4, Pages (October 2014)

Thrombocytopenia With Abnormal Liver Function Tests

Predictors of Early Treatment Discontinuation Among Patients With Genotype 1 Hepatitis C and Implications for Viral Eradication Lauren A. Beste, George.

Severe irritable bowel and functional abdominal pain syndromes: Managing the patient and health care costs George F. Longstreth, Douglas A. Drossman

Incidence of Neoplasms in Patients Who Develop Sustained Leukopenia During or After Treatment With 6-Mercaptopurine for Inflammatory Bowel Disease William.

Hepatitis C Virus Infection, Age, and Hispanic Ethnicity Increase Mortality From Liver Cancer in the United States Zobair M. Younossi, Maria Stepanova

Failure to Renew Prescriptions for Gastroprotective Agents to Patients on Continuous Nonsteroidal Anti-inflammatory Drugs Increases Rate of Upper Gastrointestinal.

Coagulation in Liver Disease: A Guide for the Clinician

Issue Highlights Clinical Gastroenterology and Hepatology

Rebecca D. Chason, Joan S. Reisch, PhD, Don C. Rockey, MD

Issue Highlights Clinical Gastroenterology and Hepatology

Epithelioid Hemangioendothelioma of the Liver

Scott K. Fung, Anna S.F. Lok Clinical Gastroenterology and Hepatology

Adverse Outcomes: Why Bad Things Happen to Good People

Angiomyolipoma of the Colon

Presentation transcript:

Nonsteroidal Anti-Inflammatory Drugs and Hepatic Toxicity: A Systematic Review of Randomized Controlled Trials in Arthritis Patients Alaa Rostom, Lawrence Goldkind, Loren Laine Clinical Gastroenterology and Hepatology Volume 3, Issue 5, Pages 489-498 (May 2005) DOI: 10.1016/S1542-3565(04)00777-3 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Proportion of patients (and 95% CI) with aminotransferase elevations >3× ULN for individual NSAIDs. (Total number of patients exposed listed below each NSAID.) Clinical Gastroenterology and Hepatology 2005 3, 489-498DOI: (10.1016/S1542-3565(04)00777-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Proportion of patients (and 95% CI) with liver-related discontinuations from the studies for individual NSAIDs. (Total number of patients exposed listed below each NSAID.) Clinical Gastroenterology and Hepatology 2005 3, 489-498DOI: (10.1016/S1542-3565(04)00777-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Proportion of patients (and 95% CI) with hepatic SAEs for individual NSAIDs. (Total number of patients exposed listed below each NSAID.) Clinical Gastroenterology and Hepatology 2005 3, 489-498DOI: (10.1016/S1542-3565(04)00777-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 4 Proportion of patients (and 95% CI) with aminotransferase elevations >3× ULN for individual NSAIDs in shorter-term studies (≤13 wk) vs longer-term studies (>13 wk). (Total number of patients exposed listed below each NSAID.) Clinical Gastroenterology and Hepatology 2005 3, 489-498DOI: (10.1016/S1542-3565(04)00777-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 5 Proportion of patients (and 95% CI) with liver-related discontinuations from the studies for individual NSAIDs in shorter-term studies (≤13 wk) vs longer-term studies (>13 wk). (Total number of patients exposed listed below each NSAID.) Clinical Gastroenterology and Hepatology 2005 3, 489-498DOI: (10.1016/S1542-3565(04)00777-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 6 Proportion of patients (and 95% CI) with aminotransferase elevations >3× ULN for lower-dose vs higher-dose diclofenac and rofecoxib. (Total number of patients exposed listed below each NSAID.) Clinical Gastroenterology and Hepatology 2005 3, 489-498DOI: (10.1016/S1542-3565(04)00777-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 7 Proportion of patients (and 95% CI) with liver-related discontinuations from the studies for lower-dose vs higher-dose diclofenac and rofecoxib. (Total number of patients exposed listed below each NSAID.) Clinical Gastroenterology and Hepatology 2005 3, 489-498DOI: (10.1016/S1542-3565(04)00777-3) Copyright © 2005 American Gastroenterological Association Terms and Conditions