How are synaptic vesicles clustered? Daniel Gitler, Department of Physiology and Cell biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev

Presynaptic terminal Postsynaptic terminal Gitler et al., J Neurosci 2004

Vesicles redistribute into the axon when synapsins are ablated 500 nm Orenbuch et al., J Neurosci 2012

Measuring vesicle mobility Darcy at al. 2006 Orenbuch et al., J Neurosci 2012

Model for vesicle clustering

Synapsins are ATP binding proteins Crystalographic structure of ATP bound to the central domain of synapsin I Do mutations in ATP binding sites affect clustering and mobilization of vesicles? Esser et al., 1998

Other topics Does mobilization of reserve vesicles require endocytosis? The basis for epilepsy in the synapsin TKO mice and in cases of human familial epilepsy linked to synapsin The possibility of a functional interaction between synapsin and alpha-synuclein, a protein involved in Parkinsons disease