Volume 40, Issue 1, Pages 184-186 (January 2004) Protease inhibitors for treatment of chronic hepatitis C—a new target for the magic bullet identified  Peter Ferenci  Journal of Hepatology  Volume 40, Issue 1, Pages 184-186 (January 2004) DOI: 10.1016/j.jhep.2003.10.015

Fig. 1 Simplified scheme of activation of type I interferons (IFNs) by viral infections. HCVs like most viruses have evolved strategies to block and interfere with the IFN pathway. (1) Blocking of IFN induction/expression by a serine protease in the NS3/NS4 region inhibits the activation of IRF-3 [13]. (2) Interaction of PKR with HCV E2 protein abolishes antiviral activity of IFN [3]. Abbreviations: IKK, IκB kinase; IRF, IFN-regulatory factor; ISG, IFN-stimulated genes; JAK, Janus kinase; Mx, myxovirus-resistance proteins; OAS, oligoadenylate synthetase; PKR, IFN-inducible protein kinase; STAT, signal transducer and activator of transcription; TYK, tyrosine kinase. Journal of Hepatology 2004 40, 184-186DOI: (10.1016/j.jhep.2003.10.015)