The effects of diethyldithiocarbamate, a SOD inhibitor, on endothelial function in sedentary and exercised db/db mice  M. Khazaei, F. Moien-Afshari, S. Elmi, A. Mirdamadi, I. Laher  Pathophysiology  Volume 16, Issue 1, Pages 15-18 (June 2009) DOI: 10.1016/j.pathophys.2008.11.002 Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Effect of DDC and DDC plus SOD incubation on ACh-induced endothelium-dependent relaxation of the aortic rings in sedentary and exercised WT and diabetic db/db mice. In WT mice, relaxation to ACh was slightly suppressed by incubation with DDC and maximal response was re-established when SOD was added to the bath (A, B and C). In sedentary db/db mice, response to ACh was significantly lower than the WT mice (°p<0.05 WT compared to db/db). DDC incubation did not decrease the response significantly. However, adding SOD to the bath in the presence of DDC increased the response significantly to the level of the WT mice (**p<0.05). In mild (Exe I) and moderate exercise (Exe II) diabetic mice, incubation with DDC significantly suppressed ACh response to the level of sedentary db/db mice (**p<0.05) (D and E). Adding SOD to the bath, in the presence of DDC, improved the response back to the initial level (*p<0.05) (D and E). Pathophysiology 2009 16, 15-18DOI: (10.1016/j.pathophys.2008.11.002) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions