Volume 95, Issue 5, Pages (May 2019)

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Volume 95, Issue 5, Pages 1181-1189 (May 2019) Performance of creatinine- or cystatin C–based equations to estimate glomerular filtration rate in sub-Saharan African populations Justine B. Bukabau, Eric Yayo, Appolinaire Gnionsahé, Dagui Monnet, Hans Pottel, Etienne Cavalier, Aliocha Nkodila, Jean Robert R. Makulo, Vieux M. Mokoli, François B. Lepira, Nazaire M. Nseka, Jean-Marie Krzesinski, Ernest K. Sumaili, Pierre Delanaye Kidney International Volume 95, Issue 5, Pages 1181-1189 (May 2019) DOI: 10.1016/j.kint.2018.11.045 Copyright © 2019 International Society of Nephrology Terms and Conditions

Kidney International 2019 95, 1181-1189DOI: (10.1016/j.kint.2018.11.045) Copyright © 2019 International Society of Nephrology Terms and Conditions

Figure 1 Bland and Altman plots for estimating glomerular filtration rate (eGFR) and measured glomerular filtration rate (mGFR) in the whole population. The x axis represents the mean of eGFR and mGFR. The y axis represents the difference between eGFR and mGFR. The first line has graphs of creatinine-based equations; the second line, graphs of cystatin C–based equations; and the third line, graphs of combined equations. In each plot, the central dotted line represents bias, and the range between 2 other lines represents 95% limits of agreement (=1.96 × SD). Arrows represent outliers. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CKD-EPI combined, Chronic Kidney Disease Epidemiology Collaboration equation combining creatinine and cystatin C; CKD-EPI combined ef, Chronic Kidney Disease Epidemiology Collaboration equation with the ethnic factor; CKD-EPI CysC, Chronic Kidney Disease Epidemiology Collaboration equation based on cystatin C; FAS combined, Full Age Spectrum equation based on creatinine and cystatin C with White Q; FAS combined af, Full Age Spectrum equation combined with African Q; FAS CysC, Full Age Spectrum equation based on cystatin C; FAS SCr, Full Age Spectrum equation based on serum creatinine with White Q; FAS SCr af, Full Age Spectrum equation based on serum creatinine with African Q; MDRD, Modification of Diet in Renal Disease; MDRD ef, Modification of Diet in Renal Disease with the ethnic factor. Kidney International 2019 95, 1181-1189DOI: (10.1016/j.kint.2018.11.045) Copyright © 2019 International Society of Nephrology Terms and Conditions

Figure 2 Comparison of measured glomerular filtration rate (mGFR) values in healthy Whites, Congolese, and Ivorian subjects. Solid gray circles represent mGFR results and solid black lines represent 2.5th percentile (Pct), 50th Pct, and 97.5th Pct for mGFR in the Ivorian population (n = 237).18 Solid black circles with error bars represent upper and lower reference limits obtained from the meta-analysis including 633 White potential living kidney donors.26 Added white circles represent Congolese healthy subjects (n = 95). Kidney International 2019 95, 1181-1189DOI: (10.1016/j.kint.2018.11.045) Copyright © 2019 International Society of Nephrology Terms and Conditions