C1-esterase inhibitor reduces reperfusion injury after lung transplantation Mirela Scherer, MD, Stefanos Demertzis, MD, PhD, Frank Langer, MD, Anton Moritz,

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Presentation transcript:

C1-esterase inhibitor reduces reperfusion injury after lung transplantation Mirela Scherer, MD, Stefanos Demertzis, MD, PhD, Frank Langer, MD, Anton Moritz, MD, PhD, Hans-Joachim Schäfers, MD, PhD The Annals of Thoracic Surgery Volume 73, Issue 1, Pages 233-238 (January 2002) DOI: 10.1016/S0003-4975(01)03235-0

Fig 1 Values for alveolar-arterial oxygen difference as a function of time (means ± standard deviation).*p < 0.05 controls (C) versus Euro-Collins reperfused (EC) group, **p < 0.05 EC group versus C1-esterase inhibitor (C1-INH) group. The Annals of Thoracic Surgery 2002 73, 233-238DOI: (10.1016/S0003-4975(01)03235-0)

Fig 2 Values for pulmonary vascular resistance as a function of time (means ± standard deviation). *p < 0.05 controls (C) versus Euro-Collins reperfused (EC) group, **p < 0.05 EC group versus C1-esterase inhibitor (C1-INH) group. The Annals of Thoracic Surgery 2002 73, 233-238DOI: (10.1016/S0003-4975(01)03235-0)

Fig 3 Values for β-N-acetylglucosaminidase as a function of time (means ± standard deviation). *p < 0.05 controls (C) versus Euro-Collins reperfused (EC) group, **p < 0.05 EC group versus C1-esterase inhibitor (C1-INH) group. The Annals of Thoracic Surgery 2002 73, 233-238DOI: (10.1016/S0003-4975(01)03235-0)

Fig 4 Extravascular lung water 180 minutes after reperfusion. *p < 0.05 Euro-Collins reperfused (EC) group versus controls (C) and C1-esterase inhibitor (C1-INH) group. The Annals of Thoracic Surgery 2002 73, 233-238DOI: (10.1016/S0003-4975(01)03235-0)

Fig 5 Histology of lung graft from the controls and C1-esterase inhibitor group. Only a minimal alveolar-interstitial leukocyte infiltrate was observed. The Annals of Thoracic Surgery 2002 73, 233-238DOI: (10.1016/S0003-4975(01)03235-0)

Fig 6 Histology of lung from a representative animal in the Euro-Collins reperfused group. A marked alveolar-interstitial leukocyte infiltrate was present. The Annals of Thoracic Surgery 2002 73, 233-238DOI: (10.1016/S0003-4975(01)03235-0)

Fig 7 Electronmicrograph of lung graft from a representative animal in the Euro-Collins reperfused group. (* = interstitial edema; N = nucleus; PMN = polymorphonuclear neutrophilic leukocyte; SM = smooth muscle.) The Annals of Thoracic Surgery 2002 73, 233-238DOI: (10.1016/S0003-4975(01)03235-0)