Jasper Pannemans, Jan Tack Gastroenterology

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Presentation transcript:

How Effective Are Secretagogues for Irritable Bowel Syndrome With Constipation Jasper Pannemans, Jan Tack Gastroenterology Volume 155, Issue 6, Pages 1677-1679 (December 2018) DOI: 10.1053/j.gastro.2018.11.005 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Mechanisms of action of secretagogues used for treatment of irritable bowel syndrome with constipation. Secretagogues increase the luminal fluid content by acting on chloride channels (linaclotide, plecanatide and lubiprostone) or the Na+/H+ exchanger 3 (NHE3) (tenapanor). Stimulatory effects are shown as green arrows while inhibitory effects are shown as red arrows. CFTR, cystic fibrosis transmembrane conductance regulator; cGMP, cyclic guanosine 3’,5’-monophosphate; ClC-2, chloride channel protein 2; EC, enterochromaffin; GC-C, guanylyl cyclase; PKG, cGMP-dependent protein kinase. Gastroenterology 2018 155, 1677-1679DOI: (10.1053/j.gastro.2018.11.005) Copyright © 2018 AGA Institute Terms and Conditions