Cardiac Transplantation in Pediatric Patients: Fifteen-Year Experience of a Single Center Jan Groetzner, MD, Bruno Reichart, MD, Ulrich Roemer, MD, Stefanie.

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Presentation transcript:

Cardiac Transplantation in Pediatric Patients: Fifteen-Year Experience of a Single Center Jan Groetzner, MD, Bruno Reichart, MD, Ulrich Roemer, MD, Stefanie Reichel, MD, Rainer Kozlik-Feldmann, MD, Andreas Tiete, MD, Joerg Sachweh, MD, Heinrich Netz, MD, Sabine Daebritz, MD The Annals of Thoracic Surgery Volume 79, Issue 1, Pages 53-60 (January 2005) DOI: 10.1016/j.athoracsur.2003.12.075

Fig 1 Kaplan-Meier cumulative survival of patients with dilated cardiomyopathy (DCM) compared to patients with congenital heart disease (CHD) in percentages. Black line = all patients; grey bars = CHD patients (n = 17); grey dots = DCM patients (n = 30). The Annals of Thoracic Surgery 2005 79, 53-60DOI: (10.1016/j.athoracsur.2003.12.075)

Fig 2 Kaplan-Meier cumulative survival of patients transplanted between 1988 and 1995 compared to patients transplanted between 1996 and 2002 in percentages. Grey bars = HTx 1996 to 2002 (n = 26); – – = HTx 1988 to 1995 (n = 24). (HTx = heart transplantation.) The Annals of Thoracic Surgery 2005 79, 53-60DOI: (10.1016/j.athoracsur.2003.12.075)

Fig 3 Actuarial freedom from acute rejection (AR) dependent on immunosuppressive regimen. (Mycophenolate mofetil [MMF] and cyclosporine or tacrolimus [black bar; n = 27] versus azathioprine or steroids and cyclosporine or tacrolimus [grey bar; n = 23].) (Aza = azathioprin.) The Annals of Thoracic Surgery 2005 79, 53-60DOI: (10.1016/j.athoracsur.2003.12.075)

Fig 4 Incidence and spectrum (bacterial [light grey box], fungal [white box], viral [dark grey box]) of infections depending on the primary immunosuppressant (cyclosporine [CsA] versus tacrolimus [Tac]) shown as number of infections per 100 survived patient days. The Annals of Thoracic Surgery 2005 79, 53-60DOI: (10.1016/j.athoracsur.2003.12.075)

Fig 5 Serum creatinine in mg/dL as a marker of renal function: preoperatively, at discharge, at the recent follow-up depending on the primary immunosuppressant agent. Light grey box = tacrolimus patients; dark grey box = cyclosporine patients. The Annals of Thoracic Surgery 2005 79, 53-60DOI: (10.1016/j.athoracsur.2003.12.075)