Volume 28, Issue 6, Pages 683-685 (December 2015) Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate  Si Hui Tan, Nick Barker  Cancer Cell  Volume 28, Issue 6, Pages 683-685 (December 2015) DOI: 10.1016/j.ccell.2015.11.004 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Inducing HOXA5 Expression in Colorectal Cancer Stem Cells by Retinoids Suppresses Wnt Signaling and Leads to Colorectal Cancer Stem Cell Differentiation (A) In the homeostatic small intestine and colon (not shown), the stem-cell-bearing crypts reside in a region of high levels of HOXA5 but do not exhibit Wnt activity. HOXA5 and Wnt signaling are mutually antagonistic, as detailed in the insets. TA cell, transit amplifying cell. (B) By applying the same principle observed in intestine during homeostasis, HOXA5 expression in colorectal cancer stem cells (CSCs) can be induced via administering retinoids. This results in differentiation of the CSCs, which then lose their self-renewal and proliferative abilities, thereby curbing tumor growth. Cancer Cell 2015 28, 683-685DOI: (10.1016/j.ccell.2015.11.004) Copyright © 2015 Elsevier Inc. Terms and Conditions