Calcium sensitizers: What have we learned over the last 25years?

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Calcium sensitizers: What have we learned over the last 25years? P. Pollesello, Z. Papp, J.Gy. Papp International Journal of Cardiology Volume 203, Pages 543-548 (January 2016) DOI: 10.1016/j.ijcard.2015.10.240 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Mechanisms by which calcium mobilizers increase intracellular calcium. AC, adenylate cyclase; PDE, phosphodiestherase; PKA, protein kinase A; RyR, ryanodine receptor; SERCA ATPase, sarcoplasmic endoplasmic ATP-ase; PLB, phospholamban; SR, sarcoplasmic reticulum. International Journal of Cardiology 2016 203, 543-548DOI: (10.1016/j.ijcard.2015.10.240) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 Chemical structure of the ‘calcium sensitizers’ pimobendan (A), levosimendan (B) and omecamtiv mecarbil (C). International Journal of Cardiology 2016 203, 543-548DOI: (10.1016/j.ijcard.2015.10.240) Copyright © 2015 The Authors Terms and Conditions