Therapeutic Dendritic Cell Vaccination of Patients with Renal Cell Carcinoma  Annika Berntsen, Poul F. Geertsen, Inge Marie Svane  European Urology  Volume 50, Issue 1, Pages 34-43 (July 2006) DOI: 10.1016/j.eururo.2006.03.061 Copyright © 2006 European Association of Urology Terms and Conditions

Fig. 1 Activation of naïve CD4 or CD8 T cells requires two independent signals. Binding of T-cell receptor (TCR) to the antigen-HLA complex on the dendritic cell (DC) delivers a signal (signal 1) that can induce activation and expansion of T cells when the costimulatory signal (signal 2) is given by binding of CD28 to B7 molecules. European Urology 2006 50, 34-43DOI: (10.1016/j.eururo.2006.03.061) Copyright © 2006 European Association of Urology Terms and Conditions