Management Options for Irritable Bowel Syndrome Michael Camilleri, MD  Mayo Clinic Proceedings  Volume 93, Issue 12, Pages 1858-1872 (December 2018) DOI: 10.1016/j.mayocp.2018.04.032 Copyright © 2018 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure Pharmacotherapy in irritable bowel syndrome. Cl = chloride; GC-C = guanylate cyclase C; 5-HT = 5-hydroxytryptamine (serotonin); NHE = sodium/hydrogen exchanger; NK2 = neurokinin 2; TSPO = translocator protein. From J Clin Med,6 with permission (Note: this is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited [CC BY 4.0]). Mayo Clinic Proceedings 2018 93, 1858-1872DOI: (10.1016/j.mayocp.2018.04.032) Copyright © 2018 Mayo Foundation for Medical Education and Research Terms and Conditions

Mayo Clinic Proceedings 2018 93, 1858-1872DOI: (10. 1016/j. mayocp Copyright © 2018 Mayo Foundation for Medical Education and Research Terms and Conditions