Possible Roles of IL-27 in the Pathogenesis of Psoriasis

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Presentation transcript:

Possible Roles of IL-27 in the Pathogenesis of Psoriasis Sayaka Shibata, Yayoi Tada, Naoko Kanda, Kiyoko Nashiro, Masahiro Kamata, Masaru Karakawa, Tomomitsu Miyagaki, Hiromichi Kai, Hidehisa Saeki, Yuji Shirakata, Shinichi Watanabe, Kunihiko Tamaki, Shinichi Sato Journal of Investigative Dermatology Volume 130, Issue 4, Pages 1034-1039 (April 2010) DOI: 10.1038/jid.2009.349 Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Serum IL-27 levels in psoriatic patients and healthy controls (a) and their correlation with PASI scores (b) or serum IFN-γ levels (c) in psoriatic patients. (a) Serum IL-27 levels in psoriatic patients were significantly higher than those in healthy controls (P<0.005, by Mann–Whitney U-test). The horizontal and error bars indicate mean±SD. (b) A significant positive correlation was found between serum IL-27 levels and PASI scores in psoriatic patients (r=0.629, P<0.005, by Spearman's rank correlation test). The solid line represents the regression line. (c) A significant positive correlation was found between serum IL-27 and IFN-γ levels (r=0.415, P<0.05, by Spearman's rank correlation test). The solid line represents the regression line. Journal of Investigative Dermatology 2010 130, 1034-1039DOI: (10.1038/jid.2009.349) Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Immunohistochemical analyses of skin lesions with psoriasis (a, d, g), atopic dermatitis (b, e, h) and of normal skin from a healthy volunteer (c, f, i). Bar=100μm. The left panels (a–c) show IL-27 staining of intermediate-power view (original magnification, × 80), the middle panels (d–f) show IL-27 staining of high-power view (original magnification, × 160), and the right panels (g–i) show staining with isotype-matched control IgG of intermediate- power view (original magnification, × 80). The arrows indicate IL-27-positive cells in psoriatic skin lesions. Representative staining of each group is shown. Journal of Investigative Dermatology 2010 130, 1034-1039DOI: (10.1038/jid.2009.349) Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Effects of IL-27 on the production of CXCL9, CXCL10, and CXCL11 and tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT1) in keratinocytes. (a) Data are mean±SD (n=4) and are representative of three independent experiments. *P<0.05 versus controls, by Mann–Whitney U-test. (b) Results are representative of four independent experiments. Journal of Investigative Dermatology 2010 130, 1034-1039DOI: (10.1038/jid.2009.349) Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Effects of IL-27 on the TNF-α-induced production of IL-1α and CCL20 in keratinocytes. Data are mean±SD (n=6) and are representative of five independent experiments. *P<0.05 versus controls with medium alone; **P<0.05 versus TNF-α alone, by Mann–Whitney U-test. Journal of Investigative Dermatology 2010 130, 1034-1039DOI: (10.1038/jid.2009.349) Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions