γ-Secretase Mutations in Hidradenitis Suppurativa: New Insights into Disease Pathogenesis Andrew E. Pink, Michael A. Simpson, Nemesha Desai, Richard C. Trembath, Jonathan N.W. Barker Journal of Investigative Dermatology Volume 133, Issue 3, Pages 601-607 (March 2013) DOI: 10.1038/jid.2012.372 Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions
Figure 1 The location of all reported mutations within the γ-secretase complex in hidradenitis suppurativa (HS). Mutations are represented as stars. All four missense mutations (p.V75I, p.D185N, p.P211R, and p.Q216P) in NCSTN are located within the ectodomain. PEN2, presenilin enhancer-2. Journal of Investigative Dermatology 2013 133, 601-607DOI: (10.1038/jid.2012.372) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions