Serum immunoglobulin a from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation Tuula Halttunen, Markku.

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Serum immunoglobulin a from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation Tuula Halttunen, Markku Mäki.

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Serum immunoglobulin a from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation Tuula Halttunen, Markku Mäki Gastroenterology Volume 116, Issue 3, Pages 566-572 (March 1999) DOI: 10.1016/S0016-5085(99)70178-2 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Silver impregnation staining shows well-deposited basement membrane at basolateral site of a T84 luminal formation (arrowhead in A). Indirect immunofluorescence staining with celiac disease patient serum IgA shows positivity at the basement membrane area (arrowhead in B), whereas healthy individual serum IgA is negative (C) (bar = 10 μm). Gastroenterology 1999 116, 566-572DOI: (10.1016/S0016-5085(99)70178-2) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Silver impregnation staining shows well-deposited basement membrane at basolateral site of a T84 luminal formation (arrowhead in A). Indirect immunofluorescence staining with celiac disease patient serum IgA shows positivity at the basement membrane area (arrowhead in B), whereas healthy individual serum IgA is negative (C) (bar = 10 μm). Gastroenterology 1999 116, 566-572DOI: (10.1016/S0016-5085(99)70178-2) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Silver impregnation staining shows well-deposited basement membrane at basolateral site of a T84 luminal formation (arrowhead in A). Indirect immunofluorescence staining with celiac disease patient serum IgA shows positivity at the basement membrane area (arrowhead in B), whereas healthy individual serum IgA is negative (C) (bar = 10 μm). Gastroenterology 1999 116, 566-572DOI: (10.1016/S0016-5085(99)70178-2) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Mean percentages of differentiated T84 cell colonies from fibroblast–epithelial cell cocultures treated with purified serum IgA from healthy or disease controls (non-CD IgA), from untreated celiac patients (untreated CD-IgA), from celiac patients on a gluten-free diet (CD-IgA on GFD), and from the same celiac patients after gluten challenge (CD-IgA after GC). The horizontal lines represent the mean values of each group. Gastroenterology 1999 116, 566-572DOI: (10.1016/S0016-5085(99)70178-2) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Effect of added patient serum IgA on TGF-β–induced T84 epithelial cell differentiation. ●, Effect of different TGF-β concentrations without serum IgA; ■, added nonceliac IgA; ▴, added celiac IgA. Values represent means ±SEM. Gastroenterology 1999 116, 566-572DOI: (10.1016/S0016-5085(99)70178-2) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 4 Immunoblotting with IMR-90 fibroblast extracellular matrices with antibodies against TGF-β (lane 1), celiac disease patient sera (lanes 2–6), and control sera (lanes 7–11). Molecular weights are indicated (60 and 120 kilodaltons). Gastroenterology 1999 116, 566-572DOI: (10.1016/S0016-5085(99)70178-2) Copyright © 1999 American Gastroenterological Association Terms and Conditions