Biochem Block Handout #8: Saccharides (sugars)

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Presentation transcript:

Biochem Block Handout #8: Saccharides (sugars) Cycle of Carbon

Aldose vs Ketose Aldoses can isomerize to ketoses via an enediol intermediate. In vivo, this requires enzymes to proceed at a reasonable rate. Has aldehyde group Has ketone group

Tetroses: Example of Stereochemistry For chiral molecules: # of stereoisomers = 2n, where n = # of chiral carbons. Recall that a chiral carbon must have 4 different groups bound to it. Thus carbons 2 & 3 in the sugars below are chiral; carbons 1 & 4 are not

Stereochemical relationships of the D-aldoses:

Cyclization of sugars Furanose: a 5-membered (pentagonal) ring form of the sugar, related to furan. Pyranose: a 6-membered (hexagonal) ring form of the sugar, related to pyran.

Conformations of Sugars Hexoses can be in either the “chair” or “boat” conformation. The chair is much more stable. Conformations are not isomers.

Isomeric Forms of Sugars a: OH points down b: OH points up

The glycosidic bond Formation of the glycosidic bond between two monomers in an oligosaccharide is a condensation reaction, involving the elimination of water. See below for lactose: Like the phosphodiester bond in nucleic acid and amide bond in proteins, the glycosidic bond is metastable and enzymes control its hydrolysis. Another example below: maltose, with an α(14) glycosidic bond

Amylose Helix Starch is made of 2 polymers: Amylose and amylopectin. Amylose: a linear glucose polymer with a-(1,4) linkages. Amylose can form a stable helix. The helix can bind iodine to form a bright blue complex. Used for long-term energy storage. Amylopectin: a highly branched polymer with a-(1,4) linkages. The branches come from a-(1,6) linkages.

Branching in Amylopectin Glycogen, found in animal flesh, has a similar structure. Cleavage of glucose residues occurs from non-reducing ends. Reducing ends can undergo oxidation.

Oxidation of Sugars Oxidation of monosaccharides can proceed in several ways, for example, mild oxidation of an aldose with alkaline Cu(II) (Fehling’s solution)

Blood group antigens: oligosaccharide signaling The ABO blood group antigens: The blood group substances are a set of antigenic oligosaccharides attached to the surfaces of red cells. The O oligosaccharide does not elicit antibodies in most humans. The A and B antigens are formed by addition of GalNAc or Gal, respectively, to the O oligosaccharide. Each of the A and B antigens can elicit a specific antibody. R can represent either a protein molecule or a lipid molecule.

Cartilage: a glycopolymer

Peptidoglycan synthesis Penicillin inhibits the crosslinking step. Other antibiotics act on different steps.