The PARK8 Locus in Autosomal Dominant Parkinsonism: Confirmation of Linkage and Further Delineation of the Disease-Containing Interval Alexander Zimprich,

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The PARK8 Locus in Autosomal Dominant Parkinsonism: Confirmation of Linkage and Further Delineation of the Disease-Containing Interval Alexander Zimprich, Bertram Müller-Myhsok, Matthew Farrer, Petra Leitner, Manu Sharma, Mary Hulihan, Paul Lockhart, Audrey Strongosky, Jennifer Kachergus, Donald B. Calne, Jon Stoessl, Ryan J. Uitti, Ronald F. Pfeiffer, Claudia Trenkwalder, Nikolaus Homann, Erwin Ott, Karoline Wenzel, Friedrich Asmus, John Hardy, Zbigniew Wszolek, Thomas Gasser The American Journal of Human Genetics Volume 74, Issue 1, Pages 11-19 (January 2004) DOI: 10.1086/380647 Copyright © 2004 The American Society of Human Genetics Terms and Conditions

Figure 1 Linkage analysis of all 21 pedigrees with autosomal dominant Parkinson disease. Affecteds-only multipoint LOD scores are summed across families. The American Journal of Human Genetics 2004 74, 11-19DOI: (10.1086/380647) Copyright © 2004 The American Society of Human Genetics Terms and Conditions

Figure 2 Pedigree structure of families A and D. Blackened symbols denote affected family members, and asterisks (*) indicate individuals typed with polymorphic markers. For clarity, only part of each pedigree is shown. The complete pedigrees with detailed clinical descriptions are shown elsewhere (Wszolek and Markopoulou 1999). The American Journal of Human Genetics 2004 74, 11-19DOI: (10.1086/380647) Copyright © 2004 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint LOD score plots for families A and D. The X-axis represents location in centimorgans, and the Y-axis represents LOD scores. LOD scores are shown for family A, family D, and both families combined (A+D). a, Affected-only model. b, Penetrance-dependent model. The American Journal of Human Genetics 2004 74, 11-19DOI: (10.1086/380647) Copyright © 2004 The American Society of Human Genetics Terms and Conditions