Nivolumab-induced systemic vasculitis

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Presentation transcript:

Nivolumab-induced systemic vasculitis Alison Kang, MD, Meiling Yuen, MD, Delphine J. Lee, MD, PhD JAAD Case Reports Volume 4, Issue 6, Pages 606-608 (July 2018) DOI: 10.1016/j.jdcr.2018.03.013 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Palpable and nonpalpable purpura on bilateral distal legs. The right side is worse than the left side. JAAD Case Reports 2018 4, 606-608DOI: (10.1016/j.jdcr.2018.03.013) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, CT of the abdomen and pelvis with contrast showed marked dilatation of the proximal and midjejunum, up to 4.2 cm, with contrast enhancement of the mucosa and wall edema. B, A repeat CT angiogram of the abdomen after 2 days of plasma exchange and high-dose methylprednisolone showed decrease in jejunal dilatation. JAAD Case Reports 2018 4, 606-608DOI: (10.1016/j.jdcr.2018.03.013) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Several blood vessels in the papillary dermis show fibrinoid necrosis, neutrophils, nuclear dust, and extravasated red blood cells. (Hematoxylin-eosin stain.) JAAD Case Reports 2018 4, 606-608DOI: (10.1016/j.jdcr.2018.03.013) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions