Figure S2 ARK5/NUAK1 Aurora A PKN1/PRK1 CK1g2 PAK5 HPK1/MAP4K1 ABL1

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Figure S2 ARK5/NUAK1 Aurora A PKN1/PRK1 CK1g2 PAK5 HPK1/MAP4K1 ABL1 FER LRRK2 TAK1 MLK2/MAP3K10 MLK1/MAP MLK3/MAP3 JAK3 TNK1 FLT3 ERBB4/HER4 ERBB2/HER2 EGFR FMS RET TRKA TRKB TRKC SYK YES/YES1 LCK BLK TEC TXK BTK BMX/ETK < 1% 1~10% 10~20% % Activity at 1µM of AC0010 Figure S2. AC0010 kinase profiling. Graphical representation of AC0010 selectivity against a panel of 349 kinases, based on the phylogenetic tree of human kinases. Among selected kinase targets with greater than 80% inhibition, they are JAK3, BLK and 5 TEC family members.