Lora G. Bankova, MD, Joshua A. Boyce, MD

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

What drives prescription patterns in pediatric asthma management?

Monoclonal antibodies and fusion proteins in medicine

Doina M. Racila, MD, Joel N. Kline, MD, MSc

Allergen immunotherapy: A practice parameter third update

Katharine M. Woessner, MD, FAAAAI, Andrew A. White, MD, FAAAAI

Fatty acids, inflammation, and asthma

Seema S. Aceves, MD, PhD Journal of Allergy and Clinical Immunology

Advances in food allergy in 2015

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

David A. Khan, MD Journal of Allergy and Clinical Immunology

The Editors' Choice Journal of Allergy and Clinical Immunology

Aspirin-induced urticaria and angioedema, but not bronchoconstriction, associated with cysteinyl leukotriene overproduction in 2 patients with asthma

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Fatty acids, inflammation, and asthma

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Rising prevalence of asthma is sex-specific in a US farming population

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Efren Rael, MD, FAAAAI Journal of Allergy and Clinical Immunology

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction Silvia Carraro, MD, Massimo Corradi,

Omar Tliba, PhD, DVM, Reynold A. Panettieri, MD

The future of allergy/immunology: Promising young investigators

Human TH2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1 Celine N. Parmentier, MSc, Elisabeth.

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Phillip Lieberman, MD, Michael Tankersley, MD

A survivor: The eosinophil as a regulator in asthma

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

News & Notes Journal of Allergy and Clinical Immunology

Phillip Lieberman, MD, David Golden, MD

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules Josiane S. Neves,

Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think Martin L. Moore, PhD, R.

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

The role of the T cell in asthma

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Personalized asthma therapy in blacks—the role of genetic ancestry

Autophagy: Nobel Prize 2016 and allergy and asthma research

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets Sven Létourneau, DPhil, Carsten Krieg, PhD, Giuseppe Pantaleo,

Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell–dependent manner through cysteinyl leukotriene.

News & Notes Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Cagri Yildirim-Toruner, MD, Betty Diamond, MD

Sachin K. Samuchiwal, PhD, Joshua A. Boyce, MD

Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness Michael R. Edwards, PhD, Katherine Strong,

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Sean R. Lucas, MD, MPH, Thomas A.E. Platts-Mills, MD, PhD

Clinical and pathologic perspectives on aspirin sensitivity and asthma

Measles and immunomodulation

The Editors' Choice Journal of Allergy and Clinical Immunology

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Environmental factors and eosinophilic esophagitis

News & Notes Journal of Allergy and Clinical Immunology

Advances in pediatric asthma in 2007

Safety and efficacy of repeated monthly carboplatin desensitization

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Advances in mechanisms of allergic disease in 2016

Presentation transcript:

A new spin on mast cells and cysteinyl leukotrienes: Leukotriene E4 activates mast cells in vivo Lora G. Bankova, MD, Joshua A. Boyce, MD Journal of Allergy and Clinical Immunology Volume 142, Issue 4, Pages 1056-1057 (October 2018) DOI: 10.1016/j.jaci.2018.08.008 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 LTE4 activates MCs in a montelukast-dependent fashion through CysLT1R for production of PGD2 and thromboxane A2 (TXA2). LTE4-elicited MC-derived COX products can activate bronchial smooth muscle through the TP receptors, leading to bronchoconstriction. LTE4 can also contribute to this effect through direct activation of CysLT1R on smooth muscle cells. LTE4 also elicits montelukast-independent epithelial cell activation for production of PGE2 and possibly other epithelial cell cytokines. The combined effects of PGD2, LTE4, and epithelial cell cytokines lead to LTE4-elicited inflammation that is only partially suppressed by montelukast. Journal of Allergy and Clinical Immunology 2018 142, 1056-1057DOI: (10.1016/j.jaci.2018.08.008) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions