Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients L. Meng, M. Cannesson, B.S. Alexander, Z. Yu,

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Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients L. Meng, M. Cannesson, B.S. Alexander, Z. Yu, Z.N. Kain, A.E. Cerussi, B.J. Tromberg, W.W. Mantulin British Journal of Anaesthesia Volume 107, Issue 2, Pages 209-217 (August 2011) DOI: 10.1093/bja/aer150 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Continuous MAP, CO, and SctO2 recordings from two selected patients. (a–c) Recordings during phenylephrine treatment. (d–f) Recordings during ephedrine treatment. Both agents were given during the first treatment. Vertical arrows indicate the drug administration time. British Journal of Anaesthesia 2011 107, 209-217DOI: (10.1093/bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 Measurements of MAP, CO, and SctO2 for every patient. (a–c) Measurements before (pre) and after (post) phenylephrine treatments. (d–f) Measurements before (pre) and after (post) ephedrine treatments. British Journal of Anaesthesia 2011 107, 209-217DOI: (10.1093/bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 Grouped MAP (a), CO (b), and SctO2 (c) changes after the first and second phenylephrine (Phe) and the first and second ephedrine (Eph) treatments. The blue bars represent pretreatment values; the green striped bars represent post-treatment values. *P<0.01 (first treatment vs second treatment, unpaired Student's t-test). British Journal of Anaesthesia 2011 107, 209-217DOI: (10.1093/bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions

Fig 4 Pearson's correlations between SctO2 and global haemodynamics (MAP and CO) during the first and second phenylephrine (a and b) and the first and second ephedrine treatments (Tx) (c and d). ▵=post–pre. British Journal of Anaesthesia 2011 107, 209-217DOI: (10.1093/bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions