Addition of aprotinin to organ preservation solutions decreases lung reperfusion injury Randall F Roberts, MD, Garabed P Nishanian, MD, Joseph N Carey,

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Presentation transcript:

Addition of aprotinin to organ preservation solutions decreases lung reperfusion injury Randall F Roberts, MD, Garabed P Nishanian, MD, Joseph N Carey, BS, Sevak H Darbinian, MD, Jong D Kim, MD, Yasushi Sakamaki, MD, Jerry Y Chang, BS, Vaughn A Starnes, MD, Mark L Barr, MD The Annals of Thoracic Surgery Volume 66, Issue 1, Pages 225-230 (July 1998) DOI: 10.1016/S0003-4975(98)00323-3

Fig 1 Dimethylthiazole tetrazolium assay optical density for a dose titration of aprotinin (A) at 12 and 48 hours of ischemic storage. Results for both Euro-Collins (EC) and University of Wisconsin (UW) solutions are shown for both storage times. Aprotinin doses tested included 0, 50, 150, and 350 kallikrein inactivation units per milliliter (KIU/mL). Significant comparisons of an optimal dose of 150 KIU/mL to the solutions alone include EC+A versus EC at 12 hours, p < 0.01; UW+A versus UW at 12 hours, p < 0.05; EC+A versus EC at 48 hours, p < 0.05; and UW+A versus UW at 48 hours, p < 0.001. The Annals of Thoracic Surgery 1998 66, 225-230DOI: (10.1016/S0003-4975(98)00323-3)

Fig 2 Oxygen tension (pO2) in mm Hg for all groups at 6 and 12 hours of storage. Significant comparisons at 6 hours of storage were EC+A versus EC, p < 0.001; UW+A versus UW, p < 0.001. Significant comparisons at 12 hours were EC+A versus EC, p < 0.001; UW+A versus UW, p < 0.01; and UW versus EC, p < 0.05. (A = aprotinin; EC = Euro-Collins; UW = University of Wisconsin.) The Annals of Thoracic Surgery 1998 66, 225-230DOI: (10.1016/S0003-4975(98)00323-3)

Fig 3 Alveolar–arterial oxygen difference (AaDO2) in mm Hg for all groups at 6 and 12 hours of storage. Significant comparisons at 6 hours were EC+A versus EC, p < 0.001; UW+A versus UW, p < 0.001. Significant comparisons at 12 hours were EC+A versus EC, p < 0.001; UW+A versus UW, p < 0.001; and UW versus EC, p < 0.01. (A = aprotinin; EC = Euro-Collins; UW = University of Wisconsin.) The Annals of Thoracic Surgery 1998 66, 225-230DOI: (10.1016/S0003-4975(98)00323-3)

Fig 4 Compliance for all groups at 6 and 12 hours of storage. Compliance was measured as tidal volume/change in airway pressure and expressed in mL/cm H2O. The only significant comparison at 6 hours of storage was UW+A versus EC+A, p < 0.05. Significant comparisons at 12 hours were EC+A versus EC, p < 0.001; UW+A versus UW, p < 0.01; UW versus EC, p < 0.001; and UW+A versus EC+A, p < 0.001. (A = aprotinin; EC = Euro-Collins; UW = University of Wisconsin.) The Annals of Thoracic Surgery 1998 66, 225-230DOI: (10.1016/S0003-4975(98)00323-3)

Fig 5 Capillary filtration coefficient (Kf) for all groups at 6 and 12 hours of storage. The capillary filtration coefficient was normalized to 100 g wet lung weight and expressed in mL · min−1 · mm Hg−1 · 100 g−1. Significant comparisons at 6 hours were EC+A versus EC, p < 0.001; UW+A versus UW, p < 0.001; UW versus EC, p < 0.05; UW+A versus EC+A, p < 0.01. Significant comparisons at 12 hours were EC+A versus EC, p < 0.001; UW+A versus UW, p < 0.001; and UW versus EC, p < 0.001. (A = aprotinin; EC = Euro-Collins; UW = University of Wisconsin.) The Annals of Thoracic Surgery 1998 66, 225-230DOI: (10.1016/S0003-4975(98)00323-3)