D. J. Hunter, N. Arden, F. Cicuttini, M. D. Crema, B. Dardzinski, J

Slides:

Advertisements

Similar presentations

The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis Ms L. Torres, B.A., Dr D.D. Dunlop, Ph.D., Dr C.

Advertisements

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

Imaging atlas for eligibility and on-study safety of potential shoulder adverse events in anti-NGF studies (Part 3) F.W. Roemer, C.W. Hayes, C.G. Miller,

The role of imaging modalities in the diagnosis, differential diagnosis and clinical assessment of peripheral joint osteoarthritis C.Y.J. Wenham, A.J.

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

A narrative overview of the current status of MRI of the hip and its relevance for osteoarthritis research – what we know, what has changed and where.

Atlas of individual radiographic features in osteoarthritis, revised

Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study F.W. Roemer, T. Neogi,

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study Q. Fu, J. Cao, J.B. Renner, J.M. Jordan, B. Caterson,

Imaging following acute knee trauma

Loss of anterior cruciate ligament integrity and the development of radiographic knee osteoarthritis: a sub-study of the osteoarthritis initiative V.L.

Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral.

Increased risk for radiographic osteoarthritis features in young active athletes: a cross- sectional matched case–control study F.W. Roemer, M. Jarraya,

L. Kalichman, Ph. D. , P. T. , I. Malkin, Ph. D. , M. J. Seibel, Ph. D

Imaging of non-osteochondral tissues in osteoarthritis

7th International Workshop on Osteoarthritis Imaging report: “imaging in OA – now is the time to move ahead” A. Guermazi, F. Eckstein, D. Hunter, F.

H. A. Kim, I. Kim, Y. W. Song, D. H. Kim, J. Niu, A. Guermazi, M. D

Osteoarthritis as a disease of mechanics

Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib.

Bone marrow lesions on magnetic resonance imaging in hand osteoarthritis are associated with pain and interact with synovitis R. Liu, W. Damman, M. Reijnierse,

Peripatellar synovitis: comparison between non-contrast-enhanced and contrast- enhanced MRI and association with pain. The MOST study M.D. Crema, D.T.

Positron emission tomography with 18F-FDG in osteoarthritic knee

Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score) D.J. Hunter, A. Guermazi, G.H. Lo, A.J. Grainger,

Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee.

G. E. Gold, F. Cicuttini, M. D. Crema, F. Eckstein, A. Guermazi, R

Biochemical markers of synovial inflammation – Surrogate markers of synovitis on magnetic resonance imaging? – Data from the osteoarthritis initiative

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Structural correlates of pain in joints with osteoarthritis

A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI J.-P.

L. A. MacFarlane, H. Yang, J. E. Collins, A. Guermazi, M. H. Jones, E

Volumetric and semiquantitative assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis: a comparison of contrast-enhanced and.

C.P. Neu Osteoarthritis and Cartilage

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

S. Reichenbach, M. D. , A. Guermazi, M. D. , J. Niu, M. B. B. S. , D

F. Eckstein, A. Guermazi, G. Gold, J. Duryea, M. -P

Radiographic and MRI assessment in osteoarthritis efficacy studies and anti-nerve growth factor programs: Characteristics and differences A. Guermazi,

Hand osteoarthritis and bone mineral density in postmenopausal women; clinical relevance to hand function, pain and disability H.E. El-Sherif, M.D.,

Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced.

M. K. Javaid, J. A. Lynch, I. Tolstykh, A. Guermazi, F. Roemer, P

L. Menashe, K. Hirko, E. Losina, M. Kloppenburg, W. Zhang, L. Li, D. J

S. Sonne-Holm, M.D., Dr. Sci., S. Jacobsen, M.D.

The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis Ms L. Torres, B.A., Dr D.D. Dunlop, Ph.D., Dr.

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial M. Henriksen, D.J.

D. Hayashi, F.W. Roemer, A. Guermazi Osteoarthritis and Cartilage

Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study D.

Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis.

Imaging Biomarker Validation and Qualification Report: Sixth OARSI Workshop on Imaging in Osteoarthritis combined with Third OA Biomarkers Workshop D.J.

Comments on Beattie et al

F.W. Roemer, M.D. Osteoarthritis and Cartilage

Osteoarthritis and Cartilage

Relevance of imaging in anti nerve growth factor inhibitor (aNGF) studies with a focus on eligibility and on-study safety – A pictorial overview F.W.

Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis – the.

Spectrum of meniscal pathology in osteoarthritis revisited - from signal change to complete destruction. M. Jarraya, F.W. Roemer, M. Englund, M.D. Crema,

G. H. Lo, M. D. , M. Sc. , J. Niu, M. D. , D. Sc. , C. E. McLennan, M

Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography N.J. Willett, T. Thote, M. Hart,

D.J. Hunter Osteoarthritis and Cartilage

The association between hip bone marrow lesions and bone mineral density: a cross- sectional and longitudinal population-based study H. Ahedi, D. Aitken,

D. J. Hunter, R. D. Altman, F. Cicuttini, M. D. Crema, J. Duryea, F

Synovitis and the risk of knee osteoarthritis: the MOST Study

The association between meniscal damage of the posterior horns and posterior localized synovitis detected on T1-weighted contrast-enhanced MRI: the most.

Susceptibility artifacts detected on 3T MRI of the knee: frequency, change over time and associations with radiographic findings: data from the Joints.

The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies

Osteoarthritis and Cartilage

Examining a whole-organ magnetic resonance imaging scoring system for osteoarthritis of the knee using Rasch analysis P.G. Conaghan, M.B.B.S., Ph.D.,

Trapeziometacarpal subluxation predisposes to incident trapeziometacarpal osteoarthritis (OA): the Framingham study D.J. Hunter, M.B.B.S., Ph.D., Y.

Value of tomosynthesis for lesion evaluation of small joints in osteoarthritic hands using the OARSI score K. Martini, A.S. Becker, R. Guggenberger,

Osteoarthritis year 2012 in review: imaging

Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea I.J. Kim, D.H. Kim, J.Y.

Presentation transcript:

OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis D.J. Hunter, N. Arden, F. Cicuttini, M.D. Crema, B. Dardzinski, J. Duryea, A. Guermazi, I.K. Haugen, M. Kloppenburg, E. Maheu, C.G. Miller, J. Martel-Pelletier, R.E. Ochoa-Albíztegui, J.-P. Pelletier, C. Peterfy, F. Roemer, G.E. Gold Osteoarthritis and Cartilage Volume 23, Issue 5, Pages 732-746 (May 2015) DOI: 10.1016/j.joca.2015.03.003 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Visualization of thumb base OA. A. T1-weighted spin echo MRI shows ulnar-sided osteophytes at the base of the first metacarpal and the articulating os trapezium (arrows). In addition there is subchondral sclerosis ideally visualized on T1-weighted images (arrowhead). B. Corresponding T1-weighted fat-suppressed contrast-enhanced MRI shows concomitant synovitis surrounding the metacarpal osteophyte (black arrow) and subchondral bone marrow lesions (white arrowheads). Osteoarthritis and Cartilage 2015 23, 732-746DOI: (10.1016/j.joca.2015.03.003) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Severe OA of the DIP joints. Coronal T1-weighted MRI shows large osteophytes at the ulnar-sided heads of the second and third middle phalanges. In addition there is a subchondral erosion at the head of fourth middle phalanx visualized as a rounded hypointense lesion on T1-weighted imaging (arrowhead). Osteoarthritis and Cartilage 2015 23, 732-746DOI: (10.1016/j.joca.2015.03.003) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Representative clinical MRI in a person with hand OA. A. Coronal fat-suppressed proton density-weighted MRI reveals a small subchondral cyst in the third PIP joint. B. Coronal T1-weighted MRI depicts small osteophytes, subchondral sclerosis and cartilage loss in multiple joints including thumb IP, second DIP and third PIP joints. Osteoarthritis and Cartilage 2015 23, 732-746DOI: (10.1016/j.joca.2015.03.003) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Quantifying power-Doppler ultrasound over 36 frames of acquisition of the metacarpophalangeal joint. Osteoarthritis and Cartilage 2015 23, 732-746DOI: (10.1016/j.joca.2015.03.003) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions