Linking Intermacs to the World: Intermacs 10th Annual Meeting and Scientific Sessions Session III Linking Intermacs to the World: The Power of Collaboration   David C. Naftel, PhD Intermacs Director of Research P = presentation, M=manuscript,

Intermacs 10th Annual Meeting and Scientific Sessions NHLBI FDA Pre-Market CMS FDA Post-Market Clinicians Hospitals Industry

The Interagency Registry for Mechanically Assisted Circulatory Support Intermacs 10th Annual Meeting and Scientific Sessions The Interagency Registry Collaboration for Mechanically Assisted Circulatory Support P = presentation, M=manuscript,

Collaboration The Interagency Registry Intermacs 10th Annual Meeting and Scientific Sessions The Interagency Registry for Mechanically Assisted Circulatory Support Collaboration P = presentation, M=manuscript,

Intermacs 10th Annual Meeting and Scientific Sessions PHTS SRTR 5

Summary Hospitals and Patients Registry Data Collection Began Family of MACS Research Collaborations: 2006 – March, 2016 Summary Hospitals and Patients Registry Data Collection Began Hospitals Patients Intermacs June 2006 157 17,075 Medamacs May 2013 11 171 Pedimacs Sept 2012 66 302 P = presentation, M=manuscript,

Summary of Publications and Abstracts Registry Abstracts Publications Family of MACS Research Collaborations: 2006 – March, 2016 Summary of Publications and Abstracts Registry Abstracts Publications Intermacs 78 44 Medamacs 2 1 Pedimacs 3 Overall 83 47 Last Year 27 11 P = presentation, M=manuscript,

Family of MACS Research Collaborations: 2006 – March, 2016 Intermacs Pedimacs Medamacs Imacs Began Data Collection June 2006 Sept 2012 May 2013 Jan 2013 Total hospitals 157 66 11 20 (Individual) 278 (Total) Total patients 17,075 302 171 8497 Research proposals 253 8 5 2 Accepted proposals 1 Datasets to researchers 54 In progress studies: DCC 22 6 4 Publications 44 3 Unique authors 148 18 13 12 P = presentation, M=manuscript,

Intermacs 10th Annual Meeting and Scientific Sessions 8:20 AM Session III: Linking Intermacs to the World: The Power of Collaboration - D. Naftel Moderator Overview D. Naftel 8:30 AM Intermacs and the Scientific Registry of Transplant Recipients J. Tallaj 8:40 AM Pedimacs and the Pediatric Heart Transplant Study 8:50 AM Intermacs and the Centers for Medicare and Medicaid F. Pagani 9:05 AM Intermacs and the ISHLT Registry for Mechanically Assisted Circulatory Support (IMACS) R. Xie 9:20 AM Intermacs and Revival K. Aaronson 9

Past and Current Collaborations Intermacs 10th Annual Meeting and Scientific Sessions Past and Current Collaborations NIH + Investigators Sustaining Quality of Life of the Aged (Sustain-It) Mechanical Circulatory Support: Measures of Adjustment and Quality of Life CORA: Cardiac Outcomes Risk Assessment Pump Thrombosis Study (with FDA, Industry) Revive-It Revival   10

Past and Current Collaborations Intermacs 10th Annual Meeting and Scientific Sessions Past and Current Collaborations CMS + Investigators CMS Payments and Utilization of Durable Mechanical Circulatory Assist Devices for Advanced Heart Failure in Intermacs MEDCAC Analysis Pedimacs + Investigators Collaboration with PHTS   11

Past and Current Collaborations Intermacs 10th Annual Meeting and Scientific Sessions Past and Current Collaborations Industry Thoratec: HMII BTT Post Approval Study Thoratec: HMII DT Post Approval Study HeartWare: HVAD Pre-Market Study HeartWare: HVAD Post-Market Study HeartWare: Thoracotomy Study SynCardia: Console Analysis Berlin Heart: Humanitarian Use (consultant)   12