Genome Organization: Cohesin on the Move

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Genome Organization: Cohesin on the Move Judita Richterova, Barbora Huraiova, Juraj Gregan Molecular Cell Volume 66, Issue 4, Pages 444-445 (May 2017) DOI: 10.1016/j.molcel.2017.05.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Model for Chromatin Loop Formation Mediated by RNA Polymerases Moving Cohesin Rings along DNA to CTCF-Binding Sites Two RNA polymerases moving in opposite directions drive extrusion of chromatin loops through cohesin rings. The loop extrusion stops when cohesin encounters a DNA site occupied by CTCF on each side of a growing loop. Loop extrusion could be mediated either by a single cohesin ring or by two cohesin rings that embrace the chromatin fiber and are linked to each other either topologically or by complex formation (handcuff model). Molecular Cell 2017 66, 444-445DOI: (10.1016/j.molcel.2017.05.002) Copyright © 2017 Elsevier Inc. Terms and Conditions