Fabry disease: An underrecognized cause of proteinuria

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Presentation transcript:

Fabry disease: An underrecognized cause of proteinuria F.C. Fervenza, R. Torra, D.J. Lager Kidney International Volume 73, Issue 10, Pages 1193-1199 (May 2008) DOI: 10.1038/sj.ki.5002677 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Proteinuria (g 24 h−1) before and after start of ERT. Kidney International 2008 73, 1193-1199DOI: (10.1038/sj.ki.5002677) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Serum creatinine values before and after start of ERT. Kidney International 2008 73, 1193-1199DOI: (10.1038/sj.ki.5002677) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Angiokeratomas: the red-purple maculopapular skin lesions characteristic of the disorder. (a) Skin lesions on buttocks, and (b) lesions on the umbilicus (provided by Dr Mark R Pittelkow, Department of Dermatology, Mayo Clinic, Rochester, MN). Kidney International 2008 73, 1193-1199DOI: (10.1038/sj.ki.5002677) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 4 Glomerulus showing vacuolated podocytes (arrows) (hematoxylin and eosin, × 400). Kidney International 2008 73, 1193-1199DOI: (10.1038/sj.ki.5002677) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 5 Glomerulus showing enlarged podocytes containing cytoplasmic lamellated inclusion bodies (arrows) (toluidine blue, × 600). Kidney International 2008 73, 1193-1199DOI: (10.1038/sj.ki.5002677) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 6 Electron micrograph showing electron-dense laminated myelin figures in glomerular epithelial cells (× 5000). Kidney International 2008 73, 1193-1199DOI: (10.1038/sj.ki.5002677) Copyright © 2008 International Society of Nephrology Terms and Conditions