Smad3 Signal Transducer Regulates Skin Inflammation and Specific IgE Response in Murine Model of Atopic Dermatitis Minna Anthoni, Guoying Wang, Chuxia.

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Smad3 Signal Transducer Regulates Skin Inflammation and Specific IgE Response in Murine Model of Atopic Dermatitis Minna Anthoni, Guoying Wang, Chuxia Deng, Henrik J. Wolff, Antti I. Lauerma, Harri T. Alenius Journal of Investigative Dermatology Volume 127, Issue 8, Pages 1923-1929 (August 2007) DOI: 10.1038/sj.jid.5700809 Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Histological changes in the (g) epidermis and (h) dermis of mice skin after EC exposure to OVA or saline. The results are shown as mean±SEM. **P<0.01, ***P<0.001, ns: not statistically significant. (a and d) Hematoxylin and eosin-stained skin sections are from saline groups and (b and e) OVA groups; Masson-trichrome-stained skin sections are from OVA-treated WT and Smad3−/−mice; (d–f) Smad3−/− mice and (a–c) WT mice; bar=100μm; n=8–14 mice per group. Journal of Investigative Dermatology 2007 127, 1923-1929DOI: (10.1038/sj.jid.5700809) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Mast cells were significantly increased in OVA-sensitized Smad3−/− mice, but remained at a low level in OVA-sensitized WT mice. The number of eosinophils, CD11c-, CD3-, CD4-, and CD8-positive cells was significantly increased in mice skin after repeated EC exposures to OVA. The cells were counted under a light microscope and the results are expressed as cells per high-power field (original magnification × 40, eosinophils original magnification × 100). (a and d) Mast cells, (b and e) CD4+, (c and f) CD8+. (d–f) OVA-treated Smad3−/− mice and (a–c) OVA-treated WT mice; bar=100μm. The data are shown as mean±SEM. *P<0.05, **P<0.01, ***P<0.001, ns: not statistically significant; n=6–14 mice per group. Journal of Investigative Dermatology 2007 127, 1923-1929DOI: (10.1038/sj.jid.5700809) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 mRNA expression of cytokines in mice skin after EC exposure to OVA or saline. Real-time quantitative RT-PCR was used to analyze the mRNA expression levels. IL-6 and IL-1β mRNA levels were significantly increased in OVA-sensitized WT mice compared with OVA-sensitized Smad3−/− mice. The levels of IL-4, IFN-γ, and TNF-α mRNA were significantly higher in OVA-sensitized mice compared with saline group, but no significant difference between Smad3−/− and WT mice was detected. Bars and errors represent mean±SEM. *P<0.05, **P<0.01, ***P<0.001. NS: Not statistically significant; n=6–16 mice per group. Journal of Investigative Dermatology 2007 127, 1923-1929DOI: (10.1038/sj.jid.5700809) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Mice serum levels of OVA-specific IgE and IgG2a after EC exposure to OVA or saline. OVA-specific IgE and IgG2a levels were significantly increased in Smad3−/− and WT mice sensitized with OVA. There were no significant differences in antibody levels between OVA-sensitized WT and Smad3−/− mice. The data are shown as mean±SEM, ***P<0.001; n=7–13 mice per group. Journal of Investigative Dermatology 2007 127, 1923-1929DOI: (10.1038/sj.jid.5700809) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions