Biphasic nature of leptospirosis and relevant investigations at different stages of disease. Biphasic nature of leptospirosis and relevant investigations.

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Biphasic nature of leptospirosis and relevant investigations at different stages of disease. Biphasic nature of leptospirosis and relevant investigations at different stages of disease. Specimens 1 and 2 for serology are acute-phase specimens, 3 is a convalescent-phase sample which may facilitate detection of a delayed immune response, and 4 and 5 are follow-up samples which can provide epidemiological information, such as the presumptive infecting serogroup. (Adapted from reference586a with permission of the publisher.)‏ Paul N. Levett Clin. Microbiol. Rev. 2001; doi:10.1128/CMR.14.2.296-326.2001