Immune Reconstitution in Recipients of Photodepleted HLA-Identical Sibling Donor Stem Cell Transplantations: T Cell Subset Frequencies Predict Outcome

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Presentation transcript:

Immune Reconstitution in Recipients of Photodepleted HLA-Identical Sibling Donor Stem Cell Transplantations: T Cell Subset Frequencies Predict Outcome Zachariah A. McIver, Jan J. Melenhorst, Andrew Grim, Nicholas Naguib, Gerrit Weber, Vicki Fellowes, Hahn Khuu, David S. Stroncek, Susan F. Leitman, Minoo Battiwalla, A. John Barrett Biology of Blood and Marrow Transplantation Volume 17, Issue 12, Pages 1846-1854 (December 2011) DOI: 10.1016/j.bbmt.2011.05.017 Copyright © 2011 Terms and Conditions

Figure 1 Changes in frequency of T cell subsets after PD. Mean percentage ± SEM of the (A) CD4, (B) the CD8 T cell subsets, (C) Tregs, and (D) NK and B cells before (solid bar) and after PD (white bar). Biology of Blood and Marrow Transplantation 2011 17, 1846-1854DOI: (10.1016/j.bbmt.2011.05.017) Copyright © 2011 Terms and Conditions

Figure 2 Differences in TH9402 extrusion of T cell subsets in representative sample by flow cytometry. Biology of Blood and Marrow Transplantation 2011 17, 1846-1854DOI: (10.1016/j.bbmt.2011.05.017) Copyright © 2011 Terms and Conditions

Figure 3 T cell proliferation against CMV antigens before and after PD. Biology of Blood and Marrow Transplantation 2011 17, 1846-1854DOI: (10.1016/j.bbmt.2011.05.017) Copyright © 2011 Terms and Conditions

Figure 4 (A) Absolute lymphocyte counts during the first 100 days for patient receiving either a T cell depleted (open circles) or photodepleted (dark squares) SCT. (B) T cell chimerism during the first 100 days after SCT. Biology of Blood and Marrow Transplantation 2011 17, 1846-1854DOI: (10.1016/j.bbmt.2011.05.017) Copyright © 2011 Terms and Conditions

Figure 5 Ex vivo anti-CMV immune response in samples collected 100 days after PD and TCD SCT in the (A) CD4 and (B) CD8 T cells. Biology of Blood and Marrow Transplantation 2011 17, 1846-1854DOI: (10.1016/j.bbmt.2011.05.017) Copyright © 2011 Terms and Conditions

Figure 6 OS of patients receiving a PD SCT. Median frequency of CD4 central memory cells of 15% was used for survival curve generation (-log-rank HR 7.7, P = .006). Biology of Blood and Marrow Transplantation 2011 17, 1846-1854DOI: (10.1016/j.bbmt.2011.05.017) Copyright © 2011 Terms and Conditions