Roles of nociceptin/orphanin FQ and nociceptin/orphanin FQ peptide receptor in respiratory rhythm generation in the medulla oblongata: an in vitro study

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Roles of nociceptin/orphanin FQ and nociceptin/orphanin FQ peptide receptor in respiratory rhythm generation in the medulla oblongata: an in vitro study K. Takita, Y. Morimoto, O. Kemmotsu British Journal of Anaesthesia Volume 91, Issue 3, Pages 385-389 (September 2003) DOI: 10.1093/bja/aeg191 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 Schematic diagram of the newborn rat brainstem-spinal cord preparation ventral surface. Respiratory motoneuron activity corresponding to inspiration was recorded from the C4/C5 ventral root through a glass suction electrode. AICA=anterior inferior cerebellar artery; IX–XII=cranial nerves; and C1–C4=cervical ventral nerves. British Journal of Anaesthesia 2003 91, 385-389DOI: (10.1093/bja/aeg191) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 (a) C4 activity recorded from the in vitro preparation in standard solution. (b) 20 min after perfusion with nociceptin/orphanin FQ 10 nM. (c) 15 min after perfusion with nociceptin/orphanin FQ 10 nM and CompB 10 μM. British Journal of Anaesthesia 2003 91, 385-389DOI: (10.1093/bja/aeg191) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions