Professional Differences in Antigen Presentation to iNKT Cells Gennaro De Libero, Lucia Mori  Immunity  Volume 40, Issue 1, Pages 5-7 (January 2014) DOI: 10.1016/j.immuni.2013.12.008 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Instruction of CD8α+ DCs by iNKT Cells Lipid antigens inducing a Th1 or Th0 cell-like response (αGalCer C26:0 and C-glycoside) stimulate iNKT cells to release IFN-γ. iNKT cells also promote on CD8α+ DC upregulation of the costimulatory molecules CD40, CD80, CD70, Rae1, and CD86. These molecules positively influence iNKT cell response and also participate in bystander activation of NK cells, which in turn release IFN-γ and contribute to the Th1 cell-like response to lipid antigens. Instead, Th2 cell-inducing lipids (αGalCer C20:2) activate iNKT cells to release low amounts of IFN-γ. In addition, iNKT cells responding to these lipid antigens instruct CD8α+ DCs to upregulate surface expression of PD-L1 and PD-L2 coinhibitory molecules. These molecules engage PD-1 on bystander NK cells and negatively control their response, thus contributing to a skewed Th2 cell-like response to those lipid antigens. Immunity 2014 40, 5-7DOI: (10.1016/j.immuni.2013.12.008) Copyright © 2014 Elsevier Inc. Terms and Conditions