Hair Growth–Promoting Effects of Adiponectin In Vitro

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Hair Growth–Promoting Effects of Adiponectin In Vitro Chong Hyun Won, Hyeon Gyeong Yoo, Ki Young Park, Seung Hyun Shin, Won Seok Park, Phil June Park, Jin Ho Chung, Oh Sang Kwon, Kyu Han Kim Journal of Investigative Dermatology Volume 132, Issue 12, Pages 2849-2851 (December 2012) DOI: 10.1038/jid.2012.217 Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Expression of adiponectin (APN) receptors in human HFs. (a) Expression of AdipoR1 (APN receptor 1), (b) AdipoR2 (APN receptor 2), and (c) T-cadherin in human HFs. Scale bar= 100μm. Journal of Investigative Dermatology 2012 132, 2849-2851DOI: (10.1038/jid.2012.217) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 APN promotes hair shaft elongation in cultured human hair follicles. (a) Adiponectin (APN) enhanced the elongation of hair shaft in ex vivo organ culture. Data are based on HFs from 7 donors and 30–55 HFs per individual. (b) APN enhanced proliferations of matrix keratinocytes substantially. HFs with 5μgml-1 APN were incubated with Ki-67 antibody (1:100; Becton Dickinson, Franklin Lakes, NJ). Scale bar=100μm. (c) Quantitative immunhistomorphometry analysis of Ki-67-positive/DAPI (4',6-diamidino-2-phenylindole)-positive cells in HFs. The quantitative analysis was performed using Image J 1.44p (NIH, Bethesda, MD). Data are mean±SE from 30 HFs for each condition. (d–g) Adiponectin stimulated the secretion of growth factors from DPCs. DPCs were treated by 1, 10, or 100ngml-1 of adiponectin. mRNA expression of IGF-1, VEGF, HGF, and TGF-β1 was compared with nontreated control. (d–f) Expression of IGF-1, VEGF, and HGF mRNAs in DPCs detected by semi-quantitative reverse-transcriptase (RT)–PCR. (g) Expression of TGF-β1 mRNA of DPCs detected by semi-quantitative RT–PCR. CON, control; HGF, hepatocyte growth factor; MNX, minoxidil; TGF-β1, transforming growth factor-β1. Mean±SD, *P<0.05. Journal of Investigative Dermatology 2012 132, 2849-2851DOI: (10.1038/jid.2012.217) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions