Impaired vasodilation of peripheral arteries in response to acetylcholine in human beings with abdominal aortic aneurysm Kimihiro Komori, MD, PhD, Kyoutaro.

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Presentation transcript:

Impaired vasodilation of peripheral arteries in response to acetylcholine in human beings with abdominal aortic aneurysm Kimihiro Komori, MD, PhD, Kyoutaro Mawatari, MD, Hiroyuki Itoh, MD, Keizo Sugimachi, MD, PhD Journal of Vascular Surgery Volume 20, Issue 5, Pages 803-807 (November 1994) DOI: 10.1016/S0741-5214(94)70167-9 Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Left common, external, and internal iliac arteries were exposed and controlled with ligatures. Drug was infused below bifurcation of iliac artery with infusion pump. Blood flow was measured at about 3 cm distal external iliac artery with electromagnetic blood flow meter. Journal of Vascular Surgery 1994 20, 803-807DOI: (10.1016/S0741-5214(94)70167-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Actual recording of effect of acetylcholine (30 μg/min) and sodium nitroprusside (10 μg/min) on mean blood flow in patient with abdominal aortic aneurysm, colorectal cancer, and abdominal aortic aneurysm and rectal cancer. Both drugs were applied at arrow. Ca., cancer. Journal of Vascular Surgery 1994 20, 803-807DOI: (10.1016/S0741-5214(94)70167-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Effect of acetylcholine on mean blood flow. Infusion of acetylcholine (30 μg/min) increased mean blood flow significantly in patients with colorectal cancer, whereas in patient with abdominal aortic aneurysm it did not significantly increase blood flow. Data are mean ± SE (n = 6 observations). Ca., Cancer. Journal of Vascular Surgery 1994 20, 803-807DOI: (10.1016/S0741-5214(94)70167-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Effect of sodium nitroprusside on mean blood flow. Infusion of sodium nitroprusside (10 μg/min) increased mean blood flow significantly in patients with abdominal aortic aneurysm and colorectal cancer. No significant difference existed between two groups. Data are mean ± SE (n = 6 observations). Ca., Cancer. Journal of Vascular Surgery 1994 20, 803-807DOI: (10.1016/S0741-5214(94)70167-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions