SMITten by the Speed of Splicing Tracy L. Johnson, Manuel Ares  Cell  Volume 165, Issue 2, Pages 265-267 (April 2016) DOI: 10.1016/j.cell.2016.03.035 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Introns Can Be Spliced Immediately following Synthesis by RNA Polymerase II The splicesome (PDB ID 3JB9) is shown in yellow and RNA polymerase II (PDB ID 5C4A) is shown in blue. The catalytic centers are marked with colored dots that are about 95 Å apart. Carrillo Oesterreich et al. (2016) use single-molecule sequencing approaches to demonstrate that the splicing reaction can occur immediately after the 3′SS plus ∼27 nt of exon have been made by RNA polymerase II. This figure shows 34 nt (represented in green) between the branched A in the spliceosome and the 3′ end of the nascent pre-mRNA site in the polymerase active site. The image portrays the relative sizes and proximity of the spliceosome and RNA polymerase II as the fastest co-transcriptionally spliced introns are processed. Figure created by John Paul Donohue, UC Santa Cruz. Cell 2016 165, 265-267DOI: (10.1016/j.cell.2016.03.035) Copyright © 2016 Elsevier Inc. Terms and Conditions