The α folate receptor is highly activated in malignant pleural mesothelioma Raphael Bueno, MDa, Krishnarao Appasani, PhDa, Harriet Mercer, BSa, Susan.

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Presentation transcript:

The α folate receptor is highly activated in malignant pleural mesothelioma Raphael Bueno, MDa, Krishnarao Appasani, PhDa, Harriet Mercer, BSa, Susan Lester, MD, PhDb, David Sugarbaker, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 121, Issue 2, Pages 225-233 (February 2001) DOI: 10.1067/mtc.2001.111176 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 The nucleotide sequence of tag #37 (A) and the representation of the sequence of the α folate receptor full length mRNA transcript, its coding region, and sequence tag #37 (B). The Journal of Thoracic and Cardiovascular Surgery 2001 121, 225-233DOI: (10.1067/mtc.2001.111176) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Fluorescent in situ hybridization with an antisense probe generated on the basis of the sequence of tag #37 of normal pleura (A) and normal lung (B). Fallopian tube adenocarcinoma (C) and malignant pleural mesothelioma (D). The Journal of Thoracic and Cardiovascular Surgery 2001 121, 225-233DOI: (10.1067/mtc.2001.111176) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Northern blot demonstrating the presence of a 1.3-kb band (marked F on the blot) in tumor samples and nearly no band in the adjacent normal controls. Columns 1 through 10 show alternating adjacent normal tissue and mesothelioma tissue from 5 separate patients. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 225-233DOI: (10.1067/mtc.2001.111176) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Immunoprecipitation with MOv 18 and Mov19 antibody on frozen section of normal pleura (A) and mesothelioma (B). Note the localization of the antibody in the membrane and cytoplasm of the mesothelioma tumor cells. The staining in adenocarcinoma of the lung tumor cells is positive (C) and in squamous carcinoma of the lung is negative (D). The Journal of Thoracic and Cardiovascular Surgery 2001 121, 225-233DOI: (10.1067/mtc.2001.111176) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions