Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trials Christof Westenfelder, Florian E. Togel

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Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trials Christof Westenfelder, Florian E. Togel Kidney International Supplements Volume 1, Issue 3, Pages 103-106 (September 2011) DOI: 10.1038/kisup.2011.24 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Treatment of severe acute renal failure (ARF) with syngeneic multipotent stromal cells (MSCs) or fibroblasts. (a) MSC administration immediately after reflow to animals with severe ARF (Fisher 344 rats) significantly improves renal function at 24 h after clamping, whereas vehicle- and fibroblast-treated animals show no such response. P=0.002, vehicle- versus MSC-treated animals; P=0.04, fibroblast- versus MSC-treated animals; P=0.05, vehicle- versus fibroblast-treated animals. (b) MSC administration significantly lowered cortical and outer medullary injury scores. (c) MSC-treated rats showed significantly higher numbers of proliferating cells, whereas it simultaneously reduced the number of apoptotic cells compared with controls. (d) PCNA, proliferating cell nuclear antigen; SCr, serum creatinine; TUNEL, terminal transferase-mediated dUTP nick-end labeling. Reproduced from Togel et al.,6 with permission from the American Physiological Society. Kidney International Supplements 2011 1, 103-106DOI: (10.1038/kisup.2011.24) Copyright © 2011 International Society of Nephrology Terms and Conditions