David R. Meldrum, M. D. , Robert F. Casper, M. D

Slides:

Advertisements

Similar presentations

Mouse strain and quality control testing: improved sensitivity of the mouse embryo assay with embryos from outbred mice Zaraq Khan, M.B.B.S., Heather S.

Advertisements

Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States David B. Seifer, M.D., Valerie.

International Committee for Monitoring Assisted Reproductive Technology (ICMART) world report: assisted reproductive technology 2003 Karl G. Nygren,

A review and meta-analysis of prospective trials comparing different catheters used for embryo transfer William M. Buckett, M.D. Fertility and Sterility

Demián Glujovsky, M.D., M.Sc., Cynthia Farquhar, M.D., M.P.H.

Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis Hye Jin Chang, M.D., Ph.D.,

Age at menarche: a predictor of diminished ovarian function?

Antonio Diez-Juan, Ph. D. , Carmen Rubio, Ph. D. , Carlos Marin, B. Sc

Exploratory randomized trial on the effect of a brief psychological intervention on emotions, quality of life, discontinuation, and pregnancy rates in.

Infertility evaluation and treatment among women in the United States

The aging oocyte—can mitochondrial function be improved?

Long-term risk of ectopic pregnancy varies by method of tubal sterilization: a whole- population study Eva Malacova, Ph.D., Anna Kemp, Ph.D., Roger Hart,

Composition of single-step media used for human embryo culture

Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success Luke Simon,

Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression

Hepatitis and reproduction

Marcos Meseguer, Ph. D. , Rebeca Santiso, Ph. D. , Nicolás Garrido, Ph

A randomized assessor-blind trial comparing highly purified hMG and recombinant FSH in a GnRH antagonist cycle with compulsory single-blastocyst transfer

Robot-assisted laparoscopy for infertility treatment: current views

Cem Atabekoglu, M. D. , Murat Sonmezer, M. D. , Sinan Özkavukcu, M. D

Ethnicity as a determinant of ovarian reserve: differences in ovarian aging between Spanish and Indian women Carlos Iglesias, M.D., Manish Banker, M.D.,

Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study Nicole Hope, M.B., B.S., Hon., Luk.

The prevalence of eating disorders in infertile women

Mouse strain and quality control testing: improved sensitivity of the mouse embryo assay with embryos from outbred mice Zaraq Khan, M.B.B.S., Heather.

Monozygotic twins in infertile patients with advanced maternal age: case reports and review of the literature Navid Esfandiari, D.V.M., Ph.D., H.C.L.D.,

How old is too old? Challenges faced by clinicians concerning age cutoffs for patients undergoing in vitro fertilization Robert L. Klitzman, M.D. Fertility.

A comparison of blood spot vs

The role of steroid hormone supplementation in non–assisted reproductive technology treatments for unexplained infertility Alexander M. Quaas, M.D.,

Optimizing the number of blastocyst stage embryos to transfer on day 5 or 6 in women 38 years of age and older: a Society for Assisted Reproductive Technology.

Proteomic analysis of individual human embryos to identify novel biomarkers of development and viability Mandy G. Katz-Jaffe, Ph.D., David K. Gardner,

With the advent of selective progesterone receptor modulators, what is the place of myoma surgery in current practice? Jacques Donnez, M.D., Ph.D., Olivier.

Robert F. Casper, M.D. Fertility and Sterility

Mieke Carine Wim Eeckhaut, Ph.D. Fertility and Sterility

Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer Caroline Smith, Ph.D., Meaghan Coyle, B.Hlth.Sc. (Acup.),

Association between prior appendectomy and/or tonsillectomy in women and subsequent pregnancy rate: a cohort study Li Wei, Ph.D., Thomas MacDonald, M.D.,

Sean Ackerman, M. D. , Julia Wenegrat, M. A. , David Rettew, M. D

Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded.

What are patients doing with their mosaic embryos

Birth outcomes after spontaneous or assisted conception among infertile Australian women aged 28 to 36 years: a prospective, population-based study Danielle.

Alice A. Chen, Ph. D. , Lei Tan, Ph. D. , Vaishali Suraj, M. S

Accuracy of FISH analysis in predicting chromosomal status in patients undergoing preimplantation genetic diagnosis Catherine M. DeUgarte, M.D., Man.

Efficacy and safety of human chorionic gonadotropin for follicular phase stimulation in assisted reproduction: a systematic review and meta-analysis

Kirstine Kirkegaard, M. D. , Johnny Juhl Hindkjaer, M. Sc

Aaron K. Styer, M. D. , Diane L. Wright, Ph. D. , H. C. L. D. , Anne M

David E. Reichman, M. D. , Stacey A. Missmer, Sc. D. , Katharine F

Optimizing the number of cleavage stage embryos to transfer on day 3 in women 38 years of age and older: a Society for Assisted Reproductive Technology.

Roberto Ensenat-Waser, Ph. D. , Antonio Pellicer, M. D. , Ph. D

Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial Antoni J. Duleba, M.D.,

S. Samuel Kim, M.D. Fertility and Sterility

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin Samuel S. Thatcher, M.D., Ph.D., Elizabeth M.

Spontaneous pregnancy and birth of a normal female from a woman with Turner syndrome and elevated gonadotropins Sarantis Livadas, M.D., Paraskevi Xekouki,

Reducing the dose of human chorionic gonadotropin in high responders does not affect the outcomes of in vitro fertilization David W. Schmidt, M.D.,,

Failed IVF cycles and the risk of subsequent preeclampsia or fetal growth restriction: a case-control exploratory study Ioanna Tsoumpou, M.D., Ahmed.

Counteraction during movement of spermatozoa by Trichomonas vaginalis observed by visual image analysis: a possible cause of female infertility Viroj.

MicroRNA: key gene expression regulators

Gonadotropin-releasing hormone agonist decreases chemotherapy-induced gonadotoxicity and premature ovarian failure in young female patients with Hodgkin.

Lapse in embryo transfer training does not negatively affect clinical pregnancy rates for reproductive endocrinology and infertility fellows Jessica.

Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis Ernesto Bosch, M.D., Elena.

Assessing the reproductive competence of individual embryos: a proposal for the validation of new “-omics” technologies Richard T. Scott, M.D., H.C.L.D.,

A review and meta-analysis of prospective trials comparing different catheters used for embryo transfer William M. Buckett, M.D. Fertility and Sterility

Transfer of two versus three embryos in women less than 40 years old undergoing frozen transfer cycles Inna Berin, M.D., Lawrence L. Engmann, M.D., Claudio.

An in vivo murine model of rosiglitazone use in pregnancy

Fei Sun, M. D. , Ph. D. , Paul Turek, M. D. , Calvin Greene, M. D

Aline Ketefian, M. D. , Jianfang Hu, Ph. D. , Alfred A. Bartolucci, Ph

Egg production predicts a doubling of in vitro fertilization pregnancy rates even within defined age and ovarian reserve categories Melissa C. Yih, M.D.,

Soluble HLA-G in the peritoneal fluid of women with endometriosis

Brooks A. Keel, Ph.D., H.C.L.D.(A.B.B.) Fertility and Sterility

Decrease in adiponectin levels in women with polycystic ovary syndrome after an oral glucose tolerance test Dimitrios Panidis, M.D., Ph.D., Dimitrios.

Ongoing pregnancy rates in intrauterine insemination are affected by late follicular- phase progesterone levels Antonio Requena, M.D., María Cruz, Ph.D.,

Ernesto Bosch, M. D. , Elena Labarta, M. D

Presentation transcript:

Aging and the environment affect gamete and embryo potential: can we intervene? David R. Meldrum, M.D., Robert F. Casper, M.D., Antonio Diez-Juan, Ph.D., Carlos Simon, M.D., Ph.D., Alice D. Domar, Ph.D., Rene Frydman, M.D., Ph.D. Fertility and Sterility Volume 105, Issue 3, Pages 548-559 (March 2016) DOI: 10.1016/j.fertnstert.2016.01.013 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Litter size in young (n = 39), old vehicle-treated (n = 15), and old coenzyme Q10–treated mice (n = 11). The number of live pups born to dams in the 13th month of age was decreased, but it normalized after CoQ10 supplementation. Each female produced only one litter during the breeding trial. Scatter plot data are shown as mean ± SEM per female. (B) Representative images of ovaries after gonadotropin stimulation (5). Fertility and Sterility 2016 105, 548-559DOI: (10.1016/j.fertnstert.2016.01.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 A proposed model based on our findings. Top: In healthy embryos with a normal energetic reserve, the mitochondrial biogenesis is low. The total amount of mtDNA is split between cells during division and thus the amount of mtDNA contained in individual blastocyst cells is lower than in cleavage-stage embryo cells; the overall embryonic mtDNA content remains the same. Bottom: In contrast, embryos with energetic stress activate mitochondrial biogenesis in an attempt to meet their energy demand; thus, the overall embryonic mtDNA content increases (122). Fertility and Sterility 2016 105, 548-559DOI: (10.1016/j.fertnstert.2016.01.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Changes in diastolic blood pressure in infertile women submitted to the Stroop Color and Word Test. Patients showing a biochemical pregnancy are shown in red, whereas patients failing to conceive are shown in blue (P<.0001). First, second, and third measurements were made after reading the three sheets, respectively, of the test. Recovery measurements were made 10 minutes after the end of testing (130). Fertility and Sterility 2016 105, 548-559DOI: (10.1016/j.fertnstert.2016.01.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions